Telomeres are highly conserved tandem nucleotide repeats that include proximal double-
stranded and distal single-stranded regions that in complex with shelterin proteins afford …

Osteosarcoma is the most common primary bone malignancy and is a neoplasm thought to
be derived from the bone‐forming mesenchymal stem cells. Aberrant activation of …

Rapid protein degradation enables cells to quickly modulate protein abundance.
Dysregulation of short-lived proteins plays essential roles in disease pathogenesis. A …

DAXX displays complex biological functions. Remarkably, DAXX overexpression is a
common feature in diverse cancers, which correlates with tumorigenesis, disease …

Simple Summary Since it was first described over two decades ago, the Alternative
Lengthening of Telomeres (ALT) pathway has been well accepted to hold clinical …

DAXX and ATRX are tumor suppressor proteins that form a histone H3. 3 chaperone
complex and are frequently mutated in cancers with the alternative lengthening of telomeres …

Cancer is a complex disease characterized by loss of cellular homeostasis through genetic
and epigenetic alterations. Emerging evidence highlights a role for histone variants and their …

Osteosarcoma, a highly malignant tumor, is characterized by widespread and recurrent
chromosomal and genetic abnormalities. In recent years, a number of elaborated …

Telomere length maintenance is essential for cellular immortalization and tumorigenesis.
5%− 10% of human cancers rely on a recombination-based mechanism termed alternative …

Telomeres are structurally nucleoprotein complexes at termini of linear chromosomes and
essential to chromosome stability/integrity. In normal human cells, telomere length erodes …