The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

Reactive oxygen species (ROS) are oxygen derivates and play an active role in vascular
biology. These compounds are generated within the vascular wall, at the level of endothelial …

Background Activated platelets exert a pro-inflammatory action that can be largely ascribed
to their ability to interact with leukocytes and modulate their activity. We hypothesized that …

Aspirin is effective in the prevention of cardiovascular events in high-risk patients. The
primary established effect of aspirin on hemostasis is to impair platelet aggregation via …

Background & Aims: Nonselective non-steroidal anti-inflammatory drugs (NSAIDs) and
cyclooxygenase-2 inhibitors (COX-2s) are used to treat a variety of arthritic and inflammatory …

Acute coronary syndromes and other manifestations of atherothrombotic disease are
primarily caused by atherosclerotic plaque rupture or fissuring and subsequent occlusive or …

Over the last decades, antiplatelet agents, mainly aspirin and P2Y12 receptor antagonists,
have significantly reduced morbidity and mortality associated with arterial thrombosis. Their …

ContextMyocardial infarction (MI) and ischemic stroke are thought to be caused by matrix
digestion by metalloproteinases (MMPs) leading to rupture of atherosclerotic plaques …

Long-chain acyl-CoA synthetases (ACSLs) catalyze the thioesterification of long-chain FAs
into their acyl-CoA derivatives. Purified ACSL4 is an arachidonic acid (20: 4)-preferring …

Background—Antagonism or deletion of the receptor (the TP) for the cyclooxygenase (COX)
product thromboxane (Tx) A2, retards atherogenesis in apolipoprotein E knockout (ApoE …