[HTML][HTML] Cytoplasmic stress granules: Dynamic modulators of cell signaling and disease
H Mahboubi, U Stochaj - Biochimica et Biophysica Acta (BBA)-Molecular …, 2017 - Elsevier
Stress granule (SG) assembly is a conserved cellular strategy to minimize stress-related
damage and promote cell survival. Beyond their fundamental role in the stress response …
damage and promote cell survival. Beyond their fundamental role in the stress response …
[HTML][HTML] Biochemical features and therapeutic potential of α-Mangostin: Mechanism of action, medicinal values, and health benefits
Abstract α-Mangostin (α-MG) is a natural xanthone obtained from the pericarps of
mangosteen. It exhibits excellent potential, including anti-cancer, neuroprotective …
mangosteen. It exhibits excellent potential, including anti-cancer, neuroprotective …
A review on cyclin-dependent kinase 5: An emerging drug target for neurodegenerative diseases
Abstract Cyclin-dependent kinase 5 (CDK5) is the serine/threonine-directed kinase mainly
found in the brain and plays a significant role in developing the central nervous system …
found in the brain and plays a significant role in developing the central nervous system …
Selective C9orf72 G-Quadruplex-Binding Small Molecules Ameliorate Pathological Signatures of ALS/FTD Models
The G-quadruplex (G4) forming C9orf72 GGGGCC (G4C2) expanded hexanucleotide repeat
(EHR) is the predominant genetic cause of amyotrophic lateral sclerosis (ALS) and …
(EHR) is the predominant genetic cause of amyotrophic lateral sclerosis (ALS) and …
[HTML][HTML] Unraveling the role of RNA mediated toxicity of C9orf72 repeats in C9-FTD/ALS
The most frequent genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal
dementia (FTD) is intronic hexanucleotide (G4C2) repeat expansions (HRE) in the C9orf72 …
dementia (FTD) is intronic hexanucleotide (G4C2) repeat expansions (HRE) in the C9orf72 …
[HTML][HTML] Emerging roles of i-motif in gene expression and disease treatment
X Luo, J Zhang, Y Gao, W Pan, Y Yang, X Li… - Frontiers in …, 2023 - frontiersin.org
As non-canonical nucleic acid secondary structures consisting of cytosine-rich nucleic acids,
i-motifs can form under certain conditions. Several i-motif sequences have been identified in …
i-motifs can form under certain conditions. Several i-motif sequences have been identified in …
[HTML][HTML] Characterizations of distinct parallel and antiparallel G-quadruplexes formed by two-repeat ALS and FTD related GGGGCC sequence
B Zhou, Y Geng, C Liu, H Miao, Y Ren, N Xu, X Shi… - Scientific reports, 2018 - nature.com
The large expansion of GGGGCC (G4C2) repeats of the C9orf72 gene have been found to
lead to the pathogenesis of devastating neurological diseases, amyotrophic lateral sclerosis …
lead to the pathogenesis of devastating neurological diseases, amyotrophic lateral sclerosis …
Protein aggregation, misfolding and consequential human neurodegenerative diseases
Proteins are major components of the biological functions in a cell. Biology demands that a
protein must fold into its stable three-dimensional structure to become functional. In an …
protein must fold into its stable three-dimensional structure to become functional. In an …
[HTML][HTML] Mechanisms of immune activation by c9orf72-expansions in amyotrophic lateral sclerosis and frontotemporal dementia
KJ Trageser, C Smith, FJ Herman, K Ono… - Frontiers in …, 2019 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are
neurodegenerative disorders with overlapping pathomechanisms, neurobehavioral features …
neurodegenerative disorders with overlapping pathomechanisms, neurobehavioral features …
[HTML][HTML] Insights into the conserved regulatory mechanisms of human and yeast aging
Aging represents a significant biological process having strong associations with cancer,
diabetes, and neurodegenerative and cardiovascular disorders, which leads to progressive …
diabetes, and neurodegenerative and cardiovascular disorders, which leads to progressive …