All transcription factors are equal, but some are more equal than others. In the 25 yr since
the gene encoding the microphthalmia-associated transcription factor (MITF) was first …

Melanocytes are melanin-producing cells found in skin, hair follicles, eyes, inner ear, bones,
heart and brain of humans. They arise from pluripotent neural crest cells and differentiate in …

In human skin, melanogenesis is a tightly regulated process. Indeed, several extracellular
signals are transduced via dedicated signalling pathways and mostly converge to MITF, a …

The occurrence of hyperpigmentation or hypopigmentation after inflammation is a common
condition in dermatology and cosmetology. Since the exact mechanism of its occurrence is …

Microphthalmia-associated transcription factor (MITF) acts as a master regulator of
melanocyte development, function and survival by modulating various differentiation and …

The zebrafish has become one of the most important model organisms to study biologial
processes in vivo. As a vertebrate that has many of the strengths of invertebrate model …

Tumours comprise multiple phenotypically distinct subpopulations of cells, some of which
are proposed to possess stem cell‐like properties, being able to self‐renew, seed and …

▪ Abstract The first mouse microphthalmia transcription factor (Mitf) mutation was discovered
over 60 years ago, and since then over 24 spontaneous and induced mutations have been …

Canonical Wnt signaling plays an important role in development and disease, regulating
transcription of target genes and stabilizing many proteins phosphorylated by glycogen …

Current opinion holds that pigment cells, melanocytes, are derived from neural crest cells
produced at the dorsal neural tube and that migrate under the epidermis to populate all parts …