Spin hyperpolarization in modern magnetic resonance

J Eills, D Budker, S Cavagnero, EY Chekmenev… - Chemical …, 2023 - ACS Publications
Magnetic resonance techniques are successfully utilized in a broad range of scientific
disciplines and in various practical applications, with medical magnetic resonance imaging …

NMR hyperpolarization techniques of gases

DA Barskiy, AM Coffey, P Nikolaou… - … A European Journal, 2017 - Wiley Online Library
Nuclear spin polarization can be significantly increased through the process of
hyperpolarization, leading to an increase in the sensitivity of nuclear magnetic resonance …

Near-unity nuclear polarization with an open-source 129Xe hyperpolarizer for NMR and MRI

P Nikolaou, AM Coffey, LL Walkup… - Proceedings of the …, 2013 - National Acad Sciences
The exquisite NMR spectral sensitivity and negligible reactivity of hyperpolarized xenon-129
(HP129Xe) make it attractive for a number of magnetic resonance applications; moreover …

Enabling Clinical Technologies for Hyperpolarized 129Xenon Magnetic Resonance Imaging and Spectroscopy

AS Khan, RL Harvey, JR Birchall… - Angewandte Chemie …, 2021 - Wiley Online Library
Hyperpolarization is a technique that can increase nuclear spin polarization with the
corresponding gains in nuclear magnetic resonance (NMR) signals by 4–8 orders of …

Xenon for NMR biosensing–inert but alert

L Schröder - Physica Medica, 2013 - Elsevier
NMR studies with hyperpolarized xenon as functionalized sensor or contrast agent recently
made notable progress in developing a new approach for detecting molecular markers and …

A 3D-printed high power nuclear spin polarizer

P Nikolaou, AM Coffey, LL Walkup… - Journal of the …, 2014 - ACS Publications
Three-dimensional printing with high-temperature plastic is used to enable spin exchange
optical pumping (SEOP) and hyperpolarization of xenon-129 gas. The use of 3D printed …

Characterizing and modeling the efficiency limits in large-scale production of hyperpolarized

MS Freeman, K Emami, B Driehuys - Physical Review A, 2014 - APS
The ability to produce liter volumes of highly-spin-polarized Xe 129 enables a wide range of
investigations, most notably in the fields of materials science and biomedical magnetic …

XeNA: An automated 'open-source'129Xe hyperpolarizer for clinical use

P Nikolaou, AM Coffey, LL Walkup, BM Gust… - Magnetic resonance …, 2014 - Elsevier
Here we provide a full report on the construction, components, and capabilities of our
consortium's “open-source” large-scale (~ 1 L/h) 129 Xe hyperpolarizer for clinical, pre …

NMR of hyperpolarised probes

C Witte, L Schröder - NMR in Biomedicine, 2013 - Wiley Online Library
Increasing the sensitivity of NMR experiments is an ongoing field of research to help realise
the exquisite molecular specificity of this technique. Hyperpolarisation of various nuclei is a …

Batch-mode clinical-scale optical hyperpolarization of Xenon-129 using an aluminum jacket with rapid temperature ramping

JR Birchall, P Nikolaou, AM Coffey, BE Kidd… - Analytical …, 2020 - ACS Publications
We present spin-exchange optical pumping (SEOP) using a third-generation (GEN-3)
automated batch-mode clinical-scale 129Xe hyperpolarizer utilizing continuous high-power …