Model-based scale-up methodologies for pharmaceutical granulation

EH Jang, YS Park, MS Kim, DH Choi - Pharmaceutics, 2020 - mdpi.com
In the pharmaceutical industry, it is a major challenge to maintain consistent quality of drug
products when the batch scale of a process is changed from a laboratory scale to a pilot or …

Dual asymmetric centrifugation efficiently produces a poloxamer-based nanoemulsion gel for topical delivery of pirfenidone

EP Chung, AR Wells, MM Kiamco, KP Leung - AAPS PharmSciTech, 2020 - Springer
This study used dual asymmetric centrifugation (DAC) to produce a topical vehicle for
Pirfenidone (Pf; 5-methyl-1-phenyl-2 [1H]-pyridone)—a Food and Drug Administration …

Development of a scalable process of film-coated bi-layer tablet containing sustained-release metoprolol succinate and immediate-release amlodipine Besylate

NTL Tuyen, LQ Nghiem, ND Tuan, PH Le - Pharmaceutics, 2021 - mdpi.com
The development of new drugs that combine active ingredients for the treatment
hypertension is critically essential owing to its offering advantages for both patients and …

An industrial case study: QbD to accelerate time-to-market of a drug product

M Testas, T da Cunha Sais, LP Medinilha, KNI Niwa… - AAPS Open, 2021 - Springer
The use of a Quality by Design (QbD) approach in the development of pharmaceutical
products is known to bring many advantages to the table, such as increased product and …

[PDF][PDF] A REVIEW ON ADVANCES IN THE DEVELOPMENT OF SPERMICIDES LOADED VAGINAL DRUG DELIVERY SYSTEM: STATE OF THE ART

MM ABDELLATIF, MA ELTABEEB… - Int J App …, 2022 - researchgate.net
Spermicides are bio-actives that might immobilize/kill the sperm in the vaginal tissues
inducing contraception in the female genitalia. To inhibit sperm viability, the spermicidal …

[PDF][PDF] Scaling Injectable Pharmaceuticals: Roadblocks And Strategies

V Pipada, SK Joshi, DJ babu Bikkina, S Zade… - researchgate.net
The scalability of parenteral formulations is crucial for bridging the gap between drug
discovery and commercialization. This review explores the multifaceted challenges …

Quantitative effects of formulation process variables on antitumor activities of doxorubicin nanoparticles

YJ Oyeniyi, AJ Yusuf - Brazilian Journal of Technology, 2019 - ojs.brazilianjournals.com.br
Background and objectives: Drug therapy failure is still a recurring clinical phenomenon
attributed to a host of factors among which are formulations shortcomings resulting from …

[PDF][PDF] and MEJÍA-PÉREZ, José Alfredo

E SALGADO-LOYO, MA CRUZ-GÓMEZ… - ecorfan.org
El Reporte de Estadísticas Sanitarias Mundiales 2020, presentado por la OMS, destaca que
la esperanza de vida (entre el año 2000 y 2016) tuvo un incremento del 21% en países en …

[PDF][PDF] Research design formation to determine quality indicators of potential api, 2. quality risks arising in the process of scaling the synthesis procedure

N Bevz, V Mishchenko, V Khomenko… - Quality Risks Arising in …, 2020 - papers.ssrn.com
Within the framework of the current pharmaceutical legislation, harmonized as much as
possible with the EU and the USA to ensure the import/export of high-quality medicines …

[PDF][PDF] Advances in antioxidant phytochemical for inflammatory skin diseases: mangiferin and naringin nanocarriers based lipids

MP Villa - 2020 - roderic.uv.es
Parece que fue ayer cuando empecé hacer el trabajo final de máster en el laboratorio y, sin
embargo, han pasado casi cinco años. Recuerdo mis primeros días intentando aprender a …