Protecting group chemistry for the cysteine thiol group has enabled a vast array of peptide
and protein chemistry over the last several decades. Increasingly sophisticated strategies for …

The central dogma of modern biology underscores the pivotal roles proteins play in diverse
biological processes, the study of which necessitates advanced methods to produce …

Highly effective yet chemoselective chemical transformation strategies enable the facile
access and precise modification of complicated biomacromolecules. In particular, the …

Disulfide-rich proteins are useful as drugs or tool molecules in biomedical studies, but their
synthesis is complicated by the difficulties associated with their folding. Here, we describe a …

Chemical synthesis of proteins with aggregable or colloidal peptide segments presents a
formidable task, as such peptides prove to be difficult for both solid-phase peptide synthesis …

The site-selective modification of peptide backbones allows an outstanding fine-tuning of
peptide conformation, folding ability, and physico-chemical and biological properties …

The inability to demulsify oil-in-water emulsions via green and efficient processes is a
challenging problem in many industrial processes. As a novel biodemulsifier, protein …

Alzheimer's disease (AD) is a chronic neurodegenerative disorder that accounts for about
60% of all diagnosed cases of dementia worldwide. Although there are currently several …

Native chemical ligation (NCL) provides a powerful solution to assemble proteins with
precise chemical features, which enables a detailed investigation of the protein structure …

One of the O-GlcNAc modifications is the protection of cells against a variety of stressors that
result in cell death. Previous experiments have focused on the overall ability of O-GlcNAc to …