Cellular mechanisms of hereditary photoreceptor degeneration–Focus on cGMP
The cellular mechanisms underlying hereditary photoreceptor degeneration are still poorly
understood, a problem that is exacerbated by the enormous genetic heterogeneity of this …
understood, a problem that is exacerbated by the enormous genetic heterogeneity of this …
Protein and signaling networks in vertebrate photoreceptor cells
KW Koch, D Dell'Orco - Frontiers in molecular neuroscience, 2015 - frontiersin.org
Vertebrate photoreceptor cells are exquisite light detectors operating under very dim and
bright illumination. The photoexcitation and adaptation machinery in photoreceptor cells …
bright illumination. The photoexcitation and adaptation machinery in photoreceptor cells …
Modeling the time evolution of the nanoparticle-protein corona in a body fluid
Background Nanoparticles in contact with biological fluids interact with proteins and other
biomolecules, thus forming a dynamic corona whose composition varies over time due to …
biomolecules, thus forming a dynamic corona whose composition varies over time due to …
Rods progressively escape saturation to drive visual responses in daylight conditions
A Tikidji-Hamburyan, K Reinhard, R Storchi… - Nature …, 2017 - nature.com
Rod and cone photoreceptors support vision across large light intensity ranges. Rods, active
under dim illumination, are thought to saturate at higher (photopic) irradiances. The extent of …
under dim illumination, are thought to saturate at higher (photopic) irradiances. The extent of …
The role of cGMP-signalling and calcium-signalling in photoreceptor cell death: perspectives for therapy development
The second messengers, cGMP and Ca 2+, have both been implicated in retinal
degeneration; however, it is still unclear which of the two is most relevant for photoreceptor …
degeneration; however, it is still unclear which of the two is most relevant for photoreceptor …
A calcium-relay mechanism in vertebrate phototransduction
KW Koch, D Dell'Orco - ACS chemical neuroscience, 2013 - ACS Publications
Calcium-signaling in cells requires a fine-tuned system of calcium-transport proteins
involving ion channels, exchangers, and ion-pumps but also calcium-sensor proteins and …
involving ion channels, exchangers, and ion-pumps but also calcium-sensor proteins and …
[PDF][PDF] Update 1 of: computational modeling approaches to structure–function analysis of G protein-coupled receptors
F Fanelli, PG De Benedetti - Chemical Reviews-Columbus, 2011 - researchgate.net
Any aspect of cell activity is regulated by extracellular signals that are recognized, decoded,
and transduced inside the cell via different classes of plasma membrane receptors. 1À3 G …
and transduced inside the cell via different classes of plasma membrane receptors. 1À3 G …
Calcium binding, structural stability and guanylate cyclase activation in GCAP1 variants associated with human cone dystrophy
D Dell'Orco, P Behnen, S Linse, KW Koch - Cellular and molecular life …, 2010 - Springer
Guanylate cyclase activating protein 1 (GCAP1) is a neuronal Ca 2+ sensor (NCS) that
regulates the activation of rod outer segment guanylate cyclases (ROS-GCs) in …
regulates the activation of rod outer segment guanylate cyclases (ROS-GCs) in …
GPCR: G protein complexes—the fundamental signaling assembly
B Jastrzebska - Amino acids, 2013 - Springer
G protein coupled receptors (GPCR) constitute the largest group of cell surface receptors
that transmit various signals across biological membranes through the binding and …
that transmit various signals across biological membranes through the binding and …
Dynamics of Conformational Ca2+-Switches in Signaling Networks Detected by a Planar Plasmonic Device
D Dell'Orco, S Sulmann, S Linse, KW Koch - Analytical chemistry, 2012 - ACS Publications
Ca2+-sensor proteins regulate a variety of intracellular processes by adopting specific
conformations in response to finely tuned changes in Ca2+-concentration. Here we present …
conformations in response to finely tuned changes in Ca2+-concentration. Here we present …