The cellular mechanisms underlying hereditary photoreceptor degeneration are still poorly
understood, a problem that is exacerbated by the enormous genetic heterogeneity of this …

Vertebrate photoreceptor cells are exquisite light detectors operating under very dim and
bright illumination. The photoexcitation and adaptation machinery in photoreceptor cells …

Background Nanoparticles in contact with biological fluids interact with proteins and other
biomolecules, thus forming a dynamic corona whose composition varies over time due to …

Rod and cone photoreceptors support vision across large light intensity ranges. Rods, active
under dim illumination, are thought to saturate at higher (photopic) irradiances. The extent of …

The second messengers, cGMP and Ca 2+, have both been implicated in retinal
degeneration; however, it is still unclear which of the two is most relevant for photoreceptor …

Calcium-signaling in cells requires a fine-tuned system of calcium-transport proteins
involving ion channels, exchangers, and ion-pumps but also calcium-sensor proteins and …

Any aspect of cell activity is regulated by extracellular signals that are recognized, decoded,
and transduced inside the cell via different classes of plasma membrane receptors. 1À3 G …

Guanylate cyclase activating protein 1 (GCAP1) is a neuronal Ca 2+ sensor (NCS) that
regulates the activation of rod outer segment guanylate cyclases (ROS-GCs) in …

G protein coupled receptors (GPCR) constitute the largest group of cell surface receptors
that transmit various signals across biological membranes through the binding and …

Ca2+-sensor proteins regulate a variety of intracellular processes by adopting specific
conformations in response to finely tuned changes in Ca2+-concentration. Here we present …