Actin dynamics in cell motility, division, and phagocytosis is regulated by complex factors
with multiple feedback loops, often leading to emergent dynamic patterns in the form of …

Migration of leukocytes is essential for the induction, maintenance, and regulation of
immune responses. On their trafficking routes, leukocytes encounter microenvironments of …

During cell migration and polarization, numerous signal transduction and cytoskeletal
components self-organize to generate localized protrusions. Although biochemical and …

Ras has been extensively studied as a promoter of cell proliferation, whereas few studies
have explored its role in migration. To investigate the direct and immediate effects of Ras …

Complex systems theory is concerned with identifying and characterizing common design
elements that are observed across diverse natural, technological and social complex …

A large fraction of human cancers contain genetic alterations within the Mitogen Activated
Protein Kinase (MAPK) signaling network that promote unpredictable phenotypes. Previous …

Migration of endothelial and many other cells requires spatiotemporal regulation of
protrusive and contractile cytoskeletal rearrangements that drive local cell shape changes …

Many biological events, such as the propagation of nerve impulses, the synchronized cell
cycles of early embryogenesis, and collective cell migration, must be coordinated with …

Mathematical and computational models can assist in gaining an understanding of cell
behavior at many levels of organization. Here, we review models in the literature that focus …

Cell motion is crucial in human health and development. Cells may migrate individually or in
highly coordinated groups. Cell motion results from complex intra-and extra-cellular …