An absolute, supraphysiologic elevation in GFR is observed early in the natural history in
10%–67% and 6%–73% of patients with type 1 and type 2 diabetes, respectively. Moreover …

There is an excessive burden of diabetes complications in low-resource settings. We
conducted a systematic review to determine the nature and frequency of diabetes …

More than two decades ago, hyperfiltration (HF) in diabetes was postulated to be a
maladaptive response observed early in the course of diabetic kidney disease (DKD), which …

Background Cardiac surgery is a leading cause of acute kidney injury (AKI). Such AKI
patients may develop progressive chronic kidney disease (CKD). Others, who appear to …

Aims/hypothesis We sought to characterise the effect of the age-related decline of GFR on
hyperfiltration in type 2 diabetes and to identify clinical characteristics associated with …

Renal stimulation tests document the dynamic response of the glomerular filtration rate
(GFR) after a single or a combination of stimuli, such as an intravenous infusion of dopamine …

Introduction A bidirectional association exists between insulin resistance (IR) and chronic
kidney disease (CKD) in Type 2 Diabetes Mellitus (T2DM). Baseline measures of IR are …

The capacity to increase glomerular filtration rate in response to an acute oral protein load is
known as the renal functional reserve; the loss of such capacity is used as a marker of …

The renal functional reserve (RFR) is the ability of the kidneys to increase renal plasma flow
and glomerular filtration rate (GFR) in response to protein intake. It is a measure of functional …

Background Microalbuminuria (MAU) is defined as an urinary albumin excretion rate
between 20–200 mg/l or 30–300 mg/day. It is a surrogate marker for endothelial dysfunction …