[PDF][PDF] Epigenetic regulation of hepatitis B virus covalently closed circular DNA: Implications for epigenetic therapy against chronic hepatitis B
Hepatitis B virus (HBV) infection represents a significant public health burden worldwide.
Although current therapeutics manage to control the disease progression, lifelong treatment …
Although current therapeutics manage to control the disease progression, lifelong treatment …
Cell and animal models for studying hepatitis B virus infection and drug development
J Hu, YY Lin, PJ Chen, K Watashi, T Wakita - Gastroenterology, 2019 - Elsevier
Many cell culture and animal models have been used to study hepatitis B virus (HBV)
replication and its effects in the liver; these have facilitated development of strategies to …
replication and its effects in the liver; these have facilitated development of strategies to …
A global scientific strategy to cure hepatitis B
PA Revill, FV Chisari, JM Block, M Dandri… - The lancet …, 2019 - thelancet.com
Chronic hepatitis B virus (HBV) infection is a global public health challenge on the same
scale as tuberculosis, HIV, and malaria. The International Coalition to Eliminate HBV (ICE …
scale as tuberculosis, HIV, and malaria. The International Coalition to Eliminate HBV (ICE …
[HTML][HTML] The role of host DNA ligases in hepadnavirus covalently closed circular DNA formation
Hepadnavirus covalently closed circular (ccc) DNA is the bona fide viral transcription
template, which plays a pivotal role in viral infection and persistence. Upon infection, the non …
template, which plays a pivotal role in viral infection and persistence. Upon infection, the non …
[HTML][HTML] Interferon-inducible ribonuclease ISG20 inhibits hepatitis B virus replication through directly binding to the epsilon stem-loop structure of viral RNA
Hepatitis B virus (HBV) replicates its DNA genome through reverse transcription of a viral
RNA pregenome. We report herein that the interferon (IFN) stimulated exoribonuclease …
RNA pregenome. We report herein that the interferon (IFN) stimulated exoribonuclease …
Preclinical profile and characterization of the hepatitis B virus core protein inhibitor ABI-H0731
ABSTRACT ABI-H0731, a first-generation hepatitis B virus (HBV) core protein inhibitor, has
demonstrated effective antiviral activity in chronic hepatitis B (CHB) patients in a phase 1b …
demonstrated effective antiviral activity in chronic hepatitis B (CHB) patients in a phase 1b …
[HTML][HTML] A role for the host DNA damage response in hepatitis B virus cccDNA formation—and beyond?
S Schreiner, M Nassal - Viruses, 2017 - mdpi.com
Chronic hepatitis B virus (HBV) infection puts more than 250 million people at a greatly
increased risk to develop end-stage liver disease. Like all hepadnaviruses, HBV replicates …
increased risk to develop end-stage liver disease. Like all hepadnaviruses, HBV replicates …
Nucleolin binds to and regulates transcription of hepatitis B virus covalently closed circular DNA minichromosome
Hepatitis B virus (HBV) remains a major public health threat with nearly 300 million people
chronically infected worldwide who are at a high risk of developing hepatocellular …
chronically infected worldwide who are at a high risk of developing hepatocellular …
Hepatitis B virus precore protein p22 inhibits alpha interferon signaling by blocking STAT nuclear translocation
Antagonism of host immune defenses against hepatitis B virus (HBV) infection by the viral
proteins is speculated to cause HBV persistence and the development of chronic hepatitis …
proteins is speculated to cause HBV persistence and the development of chronic hepatitis …
Conditional replication and secretion of hepatitis B virus genome uncover the truncated 3′ terminus of encapsidated viral pregenomic RNA
Hepatitis B virus (HBV) pregenomic RNA (pgRNA) is packaged into capsid where reverse
transcription takes place to synthesize viral DNA genome, and the encapsidated pgRNA is …
transcription takes place to synthesize viral DNA genome, and the encapsidated pgRNA is …