Transglutaminase regulation of cell function

RL Eckert, MT Kaartinen, M Nurminskaya… - Physiological …, 2014 - journals.physiology.org
Transglutaminases (TGs) are multifunctional proteins having enzymatic and scaffolding
functions that participate in regulation of cell fate in a wide range of cellular systems and are …

[HTML][HTML] Role of transglutaminase 2 in cell death, survival, and fibrosis

H Tatsukawa, K Hitomi - Cells, 2021 - mdpi.com
Transglutaminase 2 (TG2) is a ubiquitously expressed enzyme catalyzing the crosslinking
between Gln and Lys residues and involved in various pathophysiological events. Besides …

Cellular functions of tissue transglutaminase

MV Nurminskaya, AM Belkin - International review of cell and molecular …, 2012 - Elsevier
Transglutaminase 2 (TG2 or tissue transglutaminase) is a highly complex multifunctional
protein that acts as transglutaminase, GTPase/ATPase, protein disulfide isomerase, and …

[HTML][HTML] Transglutaminase 2: a molecular Swiss army knife

S Gundemir, G Colak, J Tucholski… - Biochimica et Biophysica …, 2012 - Elsevier
Transglutaminase 2 (TG2) is the most widely distributed member of the transglutaminase
family with almost all cell types in the body expressing TG2 to varying extents. In addition to …

Tissue transglutaminase: A multifunctional and multisite regulator in health and disease

Z Yao, Y Fan, L Lin, RE Kellems… - Physiological …, 2024 - journals.physiology.org
Tissue transglutaminase (TG2) is a widely distributed multifunctional protein involved in a
broad range of cellular and metabolic functions carried out in a variety of cellular …

Thermoresponsive polymer assemblies: from molecular design to theranostics application

SL Qiao, M Mamuti, HW An, H Wang - Progress in Polymer Science, 2022 - Elsevier
Molecule self-assembly is a ubiquitous phenomenon and a key driving force for constructing
nanostructures with diverse morphology and controllable size. Recently, interests in …

[HTML][HTML] Intracellular construction of topology-controlled polypeptide nanostructures with diverse biological functions

LL Li, SL Qiao, WJ Liu, Y Ma, D Wan, J Pan… - Nature …, 2017 - nature.com
Topological structures of bio-architectonics and bio-interfaces play major roles in
maintaining the normal functions of organs, tissues, extracellular matrix, and cells. In-depth …

[PDF][PDF] Hypoxia‐inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis

A Qu, M Taylor, X Xue, T Matsubara, D Metzger… - …, 2011 - Wiley Online Library
Oxygen dynamics in the liver is a central signaling mediator controlling hepatic homeostasis,
and dysregulation of cellular oxygen is associated with liver injury. Moreover, the …

[HTML][HTML] Transglutaminase 2 in human diseases

Z Szondy, I Korponay-Szabó, R Király, Z Sarang… - BioMedicine, 2017 - ncbi.nlm.nih.gov
Abstract Transglutaminase 2 (TG2) is an inducible transamidating acyltransferase that
catalyzes Ca (2+)-dependent protein modifications. In addition to being an enzyme, TG2 …

Nicotine induces apoptosis in human osteoblasts via a novel mechanism driven by H2O2 and entailing Glyoxalase 1-dependent MG-H1 accumulation leading to TG2 …

L Marinucci, S Balloni, K Fettucciari, M Bodo… - Free Radical Biology …, 2018 - Elsevier
Nicotine contained in cigarette smoke contributes to the onset of several diseases, including
osteoporosis, whose emerging pathogenic mechanism is associated with osteoblasts …