Topoisomerases introduce transient DNA breaks to relax supercoiled DNA, remove
catenanes and enable chromosome segregation. Human cells encode six topoisomerases …

Recent molecular studies have expanded the biological contexts in which topoisomerase II
(TOP2) has crucial functions, including DNA replication, transcription and chromosome …

DNA topoisomerases are enzymes that disentangle the topological problems that arise in
double-stranded DNA. Many of these can be solved by the generation of either single or …

Type II topoisomerases are ubiquitous enzymes in all branches of life that can alter DNA
superhelicity and unlink double-stranded DNA segments during processes such as …

Topoisomerase IIα (TOP2A) is a core component of mitotic chromosomes and important for
establishing mitotic chromosome condensation. The primary roles of TOP2A in mitosis have …

Mitosis is a highly dynamic process, aimed at separating identical copies of genomic
material into two daughter cells. A failure of the mitotic process generates cells that carry …

We show that Claspin, an adaptor protein required for Chk1 activation, becomes degraded
at the onset of mitosis. Claspin degradation was triggered by its interaction with, and …

Extensive damage to maternal DNA during meiosis causes infertility, birth defects and
abortions. However, it is unknown if fully grown oocytes have a mechanism to prevent the …

Type II topoisomerases are essential for resolving topologically entwined double-stranded
DNA. Although anti-topoisomerase 2 (Top2) drugs are clinically important antibiotics and …

Gastric cancer (GC) is one of the most fatal cancers in the world. Thousands of biomarkers
have been explored that might be related to survival and prognosis via database mining …