Receptor-mediated cell mechanosensing
Mechanosensing describes the ability of a cell to sense mechanical cues of its
microenvironment, including not only all components of force, stress, and strain but also …
microenvironment, including not only all components of force, stress, and strain but also …
The interplay between membrane topology and mechanical forces in regulating T cell receptor activity
T cells are critically important for host defense against infections. T cell activation is specific
because signal initiation requires T cell receptor (TCR) recognition of foreign antigen …
because signal initiation requires T cell receptor (TCR) recognition of foreign antigen …
Membrane-anchored DNA nanojunctions enable closer antigen-presenting cell–T-cell contact in elevated T-cell receptor triggering
How the engagement of a T-cell receptor to antigenic peptide-loaded major
histocompatibility complex on antigen-presenting cells (APCs) initiates intracellular …
histocompatibility complex on antigen-presenting cells (APCs) initiates intracellular …
Accumulation of dynamic catch bonds between TCR and agonist peptide-MHC triggers T cell signaling
TCR-pMHC interactions initiate adaptive immune responses, but the mechanism of how
such interactions under force induce T cell signaling is unclear. We show that force prolongs …
such interactions under force induce T cell signaling is unclear. We show that force prolongs …
Rewiring T-cell responses to soluble factors with chimeric antigen receptors
Chimeric antigen receptor (CAR)-expressing T cells targeting surface-bound tumor antigens
have yielded promising clinical outcomes, with two CD19 CAR-T cell therapies recently …
have yielded promising clinical outcomes, with two CD19 CAR-T cell therapies recently …
DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity
T cells are triggered when the T-cell receptor (TCR) encounters its antigenic ligand, the
peptide-major histocompatibility complex (pMHC), on the surface of antigen presenting cells …
peptide-major histocompatibility complex (pMHC), on the surface of antigen presenting cells …
Visualizing dynamic microvillar search and stabilization during ligand detection by T cells
E Cai, K Marchuk, P Beemiller, C Beppler… - Science, 2017 - science.org
INTRODUCTION For T cells to mount an adaptive immune response and enact cell-
mediated immunity, they must first successfully detect rare cognate antigen. This detection is …
mediated immunity, they must first successfully detect rare cognate antigen. This detection is …
Fluid shear stress enhances T cell activation through Piezo1
JM Hope, JA Dombroski, RS Pereles… - BMC biology, 2022 - Springer
Background T cell activation is a mechanical process as much as it is a biochemical
process. In this study, we used a cone-and-plate viscometer system to treat Jurkat and …
process. In this study, we used a cone-and-plate viscometer system to treat Jurkat and …
Mechanosensing through immunoreceptors
The immune response is orchestrated by a variety of immune cells. The function of each cell
is determined by the collective signals from various immunoreceptors, whose expression …
is determined by the collective signals from various immunoreceptors, whose expression …
Adoptive T cell therapies: a comparison of T cell receptors and chimeric antigen receptors
DT Harris, DM Kranz - Trends in pharmacological sciences, 2016 - cell.com
The tumor-killing properties of T cells provide tremendous opportunities to treat cancer.
Adoptive T cell therapies have begun to harness this potential by endowing a functionally …
Adoptive T cell therapies have begun to harness this potential by endowing a functionally …