Microfluidics‐based 3D cell culture models: Utility in novel drug discovery and delivery research
The implementation of microfluidic devices within life sciences has furthered the possibilities
of both academic and industrial applications such as rapid genome sequencing, predictive …
of both academic and industrial applications such as rapid genome sequencing, predictive …
Innovations in 3D tissue models of human brain physiology and diseases
ML Lovett, TJF Nieland, YTL Dingle… - Advanced functional …, 2020 - Wiley Online Library
Abstract 3D laboratory tissue cultures have emerged as an alternative to traditional 2D
culture systems that do not recapitulate native cell behavior. The discrepancy between in …
culture systems that do not recapitulate native cell behavior. The discrepancy between in …
Human decellularized adipose tissue scaffold as a model for breast cancer cell growth and drug treatments
Human adipose tissue extracellular matrix, derived through decellularization processing,
has been shown to provide a biomimetic microenvironment for adipose tissue regeneration …
has been shown to provide a biomimetic microenvironment for adipose tissue regeneration …
Cardiospheres recapitulate a niche-like microenvironment rich in stemness and cell-matrix interactions, rationalizing their enhanced functional potency for myocardial …
Cardiac stem cells (CSCs) are promising candidates for use in myocardial regenerative
therapy. We test the hypothesis that growing cardiac-derived cells as three-dimensional …
therapy. We test the hypothesis that growing cardiac-derived cells as three-dimensional …
Genome-wide gene expression analysis in cancer cells reveals 3D growth to affect ECM and processes associated with cell adhesion but not DNA repair
O Zschenker, T Streichert, S Hehlgans, N Cordes - PloS one, 2012 - journals.plos.org
Cell morphology determines cell behavior, signal transduction, protein-protein interaction,
and responsiveness to external stimuli. In cancer, these functions profoundly contribute to …
and responsiveness to external stimuli. In cancer, these functions profoundly contribute to …
Three-dimensional fibrous scaffolds with microstructures and nanotextures for tissue engineering
Much effort has been dedicated to developing scaffolds that can mimic native
microenvironments to promote tissue regeneration. A natural tissue scaffold provides not …
microenvironments to promote tissue regeneration. A natural tissue scaffold provides not …
Combination of hyaluronic acid hydrogel scaffold and PLGA microspheres for supporting survival of neural stem cells
Y Wang, YT Wei, ZH Zu, RK Ju, MY Guo… - Pharmaceutical …, 2011 - Springer
Purpose To develop a biomaterial composite for promoting proliferation and migration of
neural stem cells (NSCs), as well as angiogenesis on the materials, to rescue central …
neural stem cells (NSCs), as well as angiogenesis on the materials, to rescue central …
Electrophysiological characterization of embryonic hippocampal neurons cultured in a 3D collagen hydrogel
Rat embryonic hippocampal neurons were cultured in (1) 3D collagen hydrogels as
'entrapped'evenly distributed cells,(2) at the interface of two collagen layers (sandwich …
'entrapped'evenly distributed cells,(2) at the interface of two collagen layers (sandwich …
Electrophysiology read-out tools for brain-on-chip biotechnology
Brain-on-Chip (BoC) biotechnology is emerging as a promising tool for biomedical and
pharmaceutical research applied to the neurosciences. At the convergence between lab-on …
pharmaceutical research applied to the neurosciences. At the convergence between lab-on …
High throughput scaffold-based 3D micro-tumor array for efficient drug screening and chemosensitivity testing
Oncology drug development is greatly hampered by inefficient drug screening using 2D
culture. Herein, we present ready-to-use micro-scaffolds in 384-well format to generate …
culture. Herein, we present ready-to-use micro-scaffolds in 384-well format to generate …