Chagas disease is a chronic systemic infection transmitted by Trypanosoma cruzi. Its life
cycle consists of different stages in vector insects and host mammals. Trypanosoma cruzi …

Autophagy is a well-conserved process of self-digestion of intracellular components. T. cruzi
is a protozoan parasite with a complex life-cycle that involves insect vectors and mammalian …

Three symmetrical bis-aryl-α, β-unsaturated ketone derivatives, 2, 6-di ((E)-benzylidene)-
cyclohexan-1-one (DBC), 2, 6-bis ((E)-4-chlorobenzylidene) cyclohexan-1-one (BCC), and …

The current research work is about the synthesis of diversely functionalized unsymmetrical
mono-carbonyl curcuminoids:(1E, 4E)-1-(2-methoxy-4-nitrophenyl)-5-(4-methoxyphenyl)-2 …

Gallinamide A, originally isolated with a modest antimalarial activity, was subsequently
reisolated and characterized as a potent, selective, and irreversible inhibitor of the human …

Trypanosoma brucei is a protozoan parasite that causes Human African Trypanosomiasis
(HAT), a neglected tropical disease (NTD) that is endemic in 36 countries in sub-Saharan …

In the current study monoarylidene and unsymmetrical diarylidene cycloalkanes, MBMHP,
MABP, MBHP, and MBCP have been prepared. Their molecular structures were confirmed …

Here, we report the effect of new non-classical bioisosteres of miltefosine on Leishmania
amazonensis. Fifteen compounds were synthesized and the compound dhmtAc, containing …

Leishmania (Viannia) braziliensis is a protozoan that causes mucocutaneous leishmaniasis,
which is an infectious disease that affects more than 12 million people worldwide. The …

Abstract Quinoline and 1, 2, 3-triazoles are well-known nitrogen-based heterocycles
presenting diverse pharmacological properties, although their antileishmanial activity is still …