Overview of nanoparticulate strategies for solubility enhancement of poorly soluble drugs

KU Khan, MU Minhas, SF Badshah, M Suhail, A Ahmad… - Life Sciences, 2022 - Elsevier
Poor aqueous solubility and poor bioavailability are major issues with many pharmaceutical
industries. By some estimation, 70–90% drug candidates in development stage while up-to …

Cyclodextrins: structure, physicochemical properties and pharmaceutical applications

P Jansook, N Ogawa, T Loftsson - International journal of pharmaceutics, 2018 - Elsevier
Since their discovery over 100 years ago cyclodextrins (CDs) have been the subject of
numerous scientific publications. In 2016 alone CDs were the subject of over 2200 research …

[HTML][HTML] Progress to improve oral bioavailability and beneficial effects of resveratrol

A Chimento, F De Amicis, R Sirianni… - International journal of …, 2019 - mdpi.com
Resveratrol (3, 5, 4′-trihydroxystilbene; RSV) is a natural nonflavonoid polyphenol present
in many species of plants, particularly in grapes, blueberries, and peanuts. Several in vitro …

Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: basic approaches and practical applications

Y Kawabata, K Wada, M Nakatani, S Yamada… - International journal of …, 2011 - Elsevier
The poor oral bioavailability arising from poor aqueous solubility should make drug research
and development more difficult. Various approaches have been developed with a focus on …

[图书][B] Polymorphism in the Pharmaceutical Industry: Solid Form and Drug Development

R Hilfiker, M Von Raumer - 2019 - books.google.com
" Polymorphism in the Pharmaceutical Industry-Solid Form and Drug Development"
highlights the relevance of polymorphism in modern pharmaceutical chemistry, with a focus …

Predicting drug disposition via application of BCS: transport/absorption/elimination interplay and development of a biopharmaceutics drug disposition classification …

CY Wu, LZ Benet - Pharmaceutical research, 2005 - Springer
No Heading The Biopharmaceutics Classification System (BCS) was developed to allow
prediction of in vivo pharmacokinetic performance of drug products from measurements of …

Assessing the performance of amorphous solid dispersions

A Newman, G Knipp, G Zografi - Journal of pharmaceutical sciences, 2012 - Elsevier
The characterization and performance of stable amorphous solid dispersion systems were
evaluated in 40 research papers reporting active pharmaceutical ingredient (API) dissolution …

Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics

N Hussain, V Jaitley, AT Florence - Advanced drug delivery reviews, 2001 - Elsevier
1. Introduction aggregations of intestinal lymphatic tissue. However in this article we will
endeavour to focus on the The uptake of inert particulate matter (as opposed targeting of …

Drug delivery strategies for poorly water-soluble drugs

A Fahr, X Liu - Expert opinion on drug delivery, 2007 - Taylor & Francis
The drug candidates coming from combinatorial chemistry research and/or the drugs
selected from biologically based high-throughput screening are quite often very lipophilic, as …

[HTML][HTML] Hydrogel-forming microarray patches with solid dispersion reservoirs for transdermal long-acting microdepot delivery of a hydrophobic drug

YA Naser, IA Tekko, LK Vora, K Peng, QK Anjani… - Journal of Controlled …, 2023 - Elsevier
Hydrogel-forming microarray patches (HF-MAPs) are used to circumvent the skin barrier and
facilitate the noninvasive transdermal delivery of many hydrophilic substances. However …