Chromatin reprogramming and bone regeneration in vitro and in vivo via the microtopography-induced constriction of cell nuclei
Topographical cues on cells can, through contact guidance, alter cellular plasticity and
accelerate the regeneration of cultured tissue. Here we show how changes in the nuclear …
accelerate the regeneration of cultured tissue. Here we show how changes in the nuclear …
[HTML][HTML] Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism
EM Pujadas Liwag, X Wei, N Acosta, LM Carter, J Yang… - Genome biology, 2024 - Springer
Background B-type lamins are critical nuclear envelope proteins that interact with the three-
dimensional genomic architecture. However, identifying the direct roles of B-lamins on …
dimensional genomic architecture. However, identifying the direct roles of B-lamins on …
Nanoscale chromatin imaging and analysis platform bridges 4D chromatin organization with molecular function
Extending across multiple length scales, dynamic chromatin structure is linked to
transcription through the regulation of genome organization. However, no individual …
transcription through the regulation of genome organization. However, no individual …
[HTML][HTML] Early detection of lung cancer using artificial intelligence-enhanced optical nanosensing of chromatin alterations in field carcinogenesis
A Daneshkhah, S Prabhala, P Viswanathan… - Scientific reports, 2023 - nature.com
Supranucleosomal chromatin structure, including chromatin domain conformation, is
involved in the regulation of gene expression and its dysregulation has been associated …
involved in the regulation of gene expression and its dysregulation has been associated …
[HTML][HTML] Early screening of colorectal cancer using feature engineering with artificial intelligence-enhanced analysis of nanoscale chromatin modifications
A Chang, S Prabhala, A Daneshkhah, J Lin… - Scientific reports, 2024 - nature.com
Colonoscopy is accurate but inefficient for colorectal cancer (CRC) prevention due to the low
(~ 7 to 8%) prevalence of target lesions, advanced adenomas. We leveraged rectal mucosa …
(~ 7 to 8%) prevalence of target lesions, advanced adenomas. We leveraged rectal mucosa …
[HTML][HTML] Lipid exposure activates gene expression changes associated with estrogen receptor negative breast cancer
Improved understanding of local breast biology that favors the development of estrogen
receptor negative (ER−) breast cancer (BC) would foster better prevention strategies. We …
receptor negative (ER−) breast cancer (BC) would foster better prevention strategies. We …
Depletion of lamins B1 and B2 alters chromatin mobility and induces differential gene expression by a mesoscale-motion dependent mechanism
EM Pujadas, X Wei, N Acosta, L Carter, J Yang… - bioRxiv, 2023 - biorxiv.org
ABSTRACT BACKGROUND B-type lamins are critical nuclear envelope proteins that
interact with the 3D genomic architecture. However, identifying the direct roles of B-lamins …
interact with the 3D genomic architecture. However, identifying the direct roles of B-lamins …
[HTML][HTML] Formamide denaturation of double-stranded DNA for fluorescence in situ hybridization (FISH) distorts nanoscale chromatin structure
As imaging techniques rapidly evolve to probe nanoscale genome organization at higher
resolution, it is critical to consider how the reagents and procedures involved in sample …
resolution, it is critical to consider how the reagents and procedures involved in sample …
[HTML][HTML] Early screening of colorectal cancer using feature engineering with artificial intelligence-enhanced analysis of nanoscale chromatin modifications
A Chang, S Prabhala, A Daneshkhah, J Lin… - Research …, 2023 - ncbi.nlm.nih.gov
Colonoscopy is accurate but inefficient for colorectal cancer (CRC) prevention due to the low
(~ 7–8%) prevalence of target lesions, advanced adenomas. We leveraged rectal mucosa to …
(~ 7–8%) prevalence of target lesions, advanced adenomas. We leveraged rectal mucosa to …
[HTML][HTML] Active transcription and epigenetic reactions synergistically regulate meso-scale genomic organization
In interphase nuclei, chromatin forms dense domains of characteristic sizes, but the
influence of transcription and histone modifications on domain size is not understood. We …
influence of transcription and histone modifications on domain size is not understood. We …