For over a century, the importance of lipid metabolism in biology was recognized but difficult
to mechanistically understand due to the lack of sensitive and robust technologies for …

The field of lipidomics, as coined in 2003, has made profound advances and been rapidly
expanded. The mass spectrometry-based strategies of this analytical methodology-oriented …

Lipid coverage is crucial in comprehensive lipidomics studies challenged by high diversity in
lipid structures and wide dynamic range in lipid levels. Current state-of-the-art lipidomics …

Metabolomics based on direct mass spectrometry (MS) analysis, either by direct infusion or
flow injection of crude sample extracts, shows a great potential for metabolic fingerprinting …

Multi-dimensional mass spectrometry-based shotgun lipidomics (MDMS-SL) has made
profound advances for comprehensive analysis of cellular lipids. It represents one of the …

Introduction Helminths are parasitic worms that infect millions of people worldwide and
secrete a variety of excretory-secretory products (ESPs), including proteins, peptides, and …

Schistosoma mansoni is a parasitic helminth that infects millions of people mostly in tropical
parts of the world. Different life cycle stages of S. mansoni, that infect or develop in the …

Parasitic helminths secrete and excrete a vast array of molecules known to help skew or
suppress the host's immune response, thereby establishing a niche for sustained parasite …

Uncontrolled host immunological reactions directed against tissue-trapped eggs precipitate
a potentially lethal, pathological cascade responsible for schistosomiasis. Blocking …

Background Schistosomiasis is a harmful neglected tropical disease caused by infection
with Schistosoma spp., such as Schistosoma mansoni. Schistosoma must transition within a …