Skin sensitization is a term used to refer to the regulatory hazard known as allergic contact
dermatitis (ACD) in humans or contact hypersensitivity in rodents, an important health …

With the outbreak of COVID-19, increasingly more attention has been paid to the effects of
environmental factors on the immune system of organisms, because environmental …

Respiratory sensitization encompasses a group of diseases that manifest through airway
hyperresponsiveness and airflow limitation. Although the concerns regarding human health …

Assessing the impact of drugs and contaminants on immune responses requires
methodological approaches able to represent real-life conditions and predict long-term …

Dosimetry modeling and point of departure (POD) estimation using in vitro data are essential
for mechanism-based hazard identification and risk assessment. This study aimed to …

Abstract The FDA Modernization Act 2.0 has brought nonclinical drug evaluation into a new
era. In vitro models are widely used and play an important role in modern drug development …

Background: Pneumococcal infection of the central nervous system generates a massive
inflammatory reaction which can cause brain damage and thus contributes to unfavourable …

Die allergische Kontaktdermatitis (ACD) ist eine der häufigsten immunotoxikologischen
Erkrankungen der Haut. Hierbei wird das körperfremde Kontaktallergen vom Immunsystem …

Skóra jako największy organ ciała pokrywający jego całą zewnętrzną powierzchnię stanowi
pierwszą barierę przeciw patogenom, promieniowaniu UV oraz chemikaliom. Zbudowana …

Greater mechanistic understanding of the cutaneous pathogenesis of Stevens–Johnson
syndrome/toxic epidermal necrolysis can she Page 1 ACI 240409 CURRENT OPINION Greater …