A comprehensive review of monoamine oxidase inhibitors as Anti-Alzheimer's disease agents: A review

S Manzoor, N Hoda - European journal of medicinal chemistry, 2020 - Elsevier
Monoamine oxidases (MAO-A and MAO-B) are mammalian flavoenzyme, which catalyze the
oxidative deamination of several neurotransmitters like norepinephrine, dopamine, tyramine …

Oxidative stress and antioxidants in neurological diseases: is there still hope?

A Neves Carvalho, O Firuzi, M Joao Gama… - Current drug …, 2017 - ingentaconnect.com
Oxidative stress is a pathological feature common to a multitude of neurological diseases.
The production of reactive oxygen species (ROS) is the main mechanism underlying this …

Design and synthesis of curcumin analogues for in vivo fluorescence imaging and inhibiting copper-induced cross-linking of amyloid beta species in Alzheimer's …

X Zhang, Y Tian, Z Li, X Tian, H Sun, H Liu… - Journal of the …, 2013 - ACS Publications
In this article, we first designed and synthesized curcumin-based near-infrared (NIR)
fluorescence imaging probes for detecting both soluble and insoluble amyloid beta (Aβ) …

Oxidative stress in Alzheimer's disease: are we connecting the dots? Miniperspective

M Rosini, E Simoni, A Milelli, A Minarini… - Journal of medicinal …, 2014 - ACS Publications
Redox impairment is a prominent feature of Alzheimer's disease (AD). It has led to the
“oxidative stress hypothesis”, which proposes antioxidants as beneficial therapeutic tools in …

Xanthohumol, a polyphenol chalcone present in hops, activating Nrf2 enzymes to confer protection against oxidative damage in PC12 cells

J Yao, B Zhang, C Ge, S Peng… - Journal of agricultural and …, 2015 - ACS Publications
Xanthohumol (2′, 4′, 4-trihydroxy-6′-methoxy-3′-prenylchalcone, Xn), a polyphenol
chalcone from hops (Humulus lupulus), has received increasing attention due to its multiple …

Tacrine–trolox hybrids: a novel class of centrally active, nonhepatotoxic multi-target-directed ligands exerting anticholinesterase and antioxidant activities with low in …

E Nepovimova, J Korabecny, R Dolezal… - Journal of Medicinal …, 2015 - ACS Publications
Coupling of two distinct pharmacophores, tacrine and trolox, endowed with different
biological properties, afforded 21 hybrid compounds as novel multifunctional candidates …

Pivotal role of nitrogen heterocycles in Alzheimer's disease drug discovery

S Kumari, K Maddeboina, RD Bachu, SHS Boddu… - Drug Discovery …, 2022 - Elsevier
Alzheimer's disease (AD) is a detrimental neurodegenerative disease that progressively
worsens with time. Clinical options are limited and only provide symptomatic relief to AD …

Preventive and therapeutic potential of ascorbic acid in neurodegenerative diseases

M Moretti, DB Fraga… - CNS neuroscience & …, 2017 - Wiley Online Library
In this review, we summarize the involvement of ascorbic acid in neurodegenerative
diseases by presenting available evidence on the behavioral and biochemical effects of this …

Recent progress in multifunctional metal chelators as potential drugs for Alzheimer's disease

MA Santos, K Chand, S Chaves - Coordination Chemistry Reviews, 2016 - Elsevier
Alzheimer's disease (AD) is a chronic and irreversible neurodegenerative illness, which
involves the progressive deterioration of intellectual functions and behavioral disorders …

In vitro neuroprotective potential of the monoterpenes α-pinene and 1, 8-cineole against H2O2-induced oxidative stress in PC12 cells

M Porres-Martínez, E González-Burgos… - … für Naturforschung C, 2016 - degruyter.com
Oxidative stress is involved in the pathogenesis of several neurodegenerative diseases
such as Alzheimer's and Parkinson's diseases. Natural products are considered as …