Microbiome-based therapeutics

MT Sorbara, EG Pamer - Nature Reviews Microbiology, 2022 - nature.com
Symbiotic microorganisms inhabiting the gastrointestinal tract promote health by decreasing
susceptibility to infection and enhancing resistance to a range of diseases. In this Review …

Microbiota-mediated colonization resistance: mechanisms and regulation

G Caballero-Flores, JM Pickard, G Núñez - Nature Reviews …, 2023 - nature.com
A dense and diverse microbial community inhabits the gut and many epithelial surfaces.
Referred to as the microbiota, it co-evolved with the host and is beneficial for many host …

[HTML][HTML] The role of microbiota in infant health: from early life to adulthood

Y Yao, X Cai, Y Ye, F Wang, F Chen… - Frontiers in …, 2021 - frontiersin.org
From early life to adulthood, the microbiota play a crucial role in the health of the infant. The
microbiota in early life are not only a key regulator of infant health but also associated with …

Key bacterial taxa and metabolic pathways affecting gut short-chain fatty acid profiles in early life

N Tsukuda, K Yahagi, T Hara, Y Watanabe… - The ISME …, 2021 - academic.oup.com
Infant gut microbiota development affects the host physiology throughout life, and short-
chain fatty acids (SCFAs) are promising key metabolites mediating microbiota-host …

MAIT cells are imprinted by the microbiota in early life and promote tissue repair

MG Constantinides, VM Link, S Tamoutounour… - Science, 2019 - science.org
INTRODUCTION The microbiota promotes the maturation and homeostasis of the immune
system, in part through the release of microbial products. Early-life microbial colonization …

Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease

JM Pickard, MY Zeng, R Caruso… - Immunological …, 2017 - Wiley Online Library
The intestinal tract of mammals is colonized by a large number of microorganisms including
trillions of bacteria that are referred to collectively as the gut microbiota. These indigenous …

Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier

EC Martens, M Neumann, MS Desai - Nature Reviews Microbiology, 2018 - nature.com
The intestinal mucosal barrier is composed of epithelial cells that are protected by an
overlying host-secreted mucous layer and functions as the first line of defence against …

Healthy infants harbor intestinal bacteria that protect against food allergy

T Feehley, CH Plunkett, R Bao, SM Choi Hong… - Nature medicine, 2019 - nature.com
There has been a striking generational increase in life-threatening food allergies in
Westernized societies,. One hypothesis to explain this rising prevalence is that twenty-first …

Defining the role of Parasutterella, a previously uncharacterized member of the core gut microbiota

T Ju, JY Kong, P Stothard, BP Willing - The ISME journal, 2019 - academic.oup.com
The genus of Parasutterella has been defined as a core component of the human and
mouse gut microbiota, and has been correlated with various health outcomes. However, like …

[HTML][HTML] The commensal microbiota and viral infection: a comprehensive review

N Li, WT Ma, M Pang, QL Fan, JL Hua - Frontiers in Immunology, 2019 - frontiersin.org
The human body is inhabited by a diverse microbial community that is collectively coined as
commensal microbiota. Recent research has greatly advanced our understanding of how …