Spheroids-on-a-chip: Recent advances and design considerations in microfluidic platforms for spheroid formation and culture
A cell spheroid is a three-dimensional (3D) aggregation of cells. Synthetic, in-vitro spheroids
provide similar metabolism, proliferation, and species concentration gradients to those found …
provide similar metabolism, proliferation, and species concentration gradients to those found …
Microengineered cancer-on-a-chip platforms to study the metastatic microenvironment
R Portillo-Lara, N Annabi - Lab on a chip, 2016 - pubs.rsc.org
More than 90% of cancer-related deaths can be attributed to the occurrence of metastatic
diseases. Recent studies have highlighted the importance of the multicellular, biochemical …
diseases. Recent studies have highlighted the importance of the multicellular, biochemical …
Methods to mechanically perturb and characterize GUV-based minimal cell models
NH Wubshet, AP Liu - Computational and Structural Biotechnology Journal, 2023 - Elsevier
Cells shield organelles and the cytosol via an active boundary predominantly made of
phospholipids and membrane proteins, yet allowing communication between the …
phospholipids and membrane proteins, yet allowing communication between the …
Microfluidics used as a tool to understand and optimize membrane filtration processes
I Bouhid de Aguiar, K Schroën - Membranes, 2020 - mdpi.com
Membrane filtration processes are best known for their application in the water, oil, and gas
sectors, but also in food production they play an eminent role. Filtration processes are …
sectors, but also in food production they play an eminent role. Filtration processes are …
Magnetic particles assisted capture and release of rare circulating tumor cells using wavy-herringbone structured microfluidic devices
A wavy-herringbone (wavy-HB) structured microfluidic device was used to effectively and
selectively capture and release circulating tumor cells (CTCs) by using immunoaffinity and …
selectively capture and release circulating tumor cells (CTCs) by using immunoaffinity and …
Isolation of circulating plasma cells in multiple myeloma using CD138 antibody-based capture in a microfluidic device
MA Qasaimeh, YC Wu, S Bose, A Menachery… - Scientific reports, 2017 - nature.com
The necessity for bone marrow aspiration and the lack of highly sensitive assays to detect
residual disease present challenges for effective management of multiple myeloma (MM), a …
residual disease present challenges for effective management of multiple myeloma (MM), a …
The effect of protein expression on cancer cell capture using the Human Transferrin Receptor (CD71) as an affinity ligand
Cancer cell detection in liquid biopsies has been a widely studied application in many
microfluidic devices. The use of a common antibody, such as the epithelial cell adhesion …
microfluidic devices. The use of a common antibody, such as the epithelial cell adhesion …
Microfluidic separation of lymphoblasts for the isolation of acute lymphoblastic leukemia using the human transferrin receptor as a capture target
W Li, Y Zhang, CP Reynolds, D Pappas - Analytical chemistry, 2017 - ACS Publications
Acute lymphocytic leukemia (ALL) is the most prevalent pediatric cancer, and the peripheral
blood lymphoblast percentage is an important index for ALL diagnosis and prognosis. We …
blood lymphoblast percentage is an important index for ALL diagnosis and prognosis. We …
3D cellular invasion platforms: how do paper-based cultures stack up?
RM Kenney, CC Lloyd, NA Whitman… - Chemical …, 2017 - pubs.rsc.org
Cellular invasion is the gateway to metastasis, which is the leading cause of cancer-related
deaths. Invasion is driven by a number of chemical and mechanical stresses that arise in the …
deaths. Invasion is driven by a number of chemical and mechanical stresses that arise in the …
一种力-电协同驱动的细胞微流控培养腔理论模型
王兆伟， 武晓刚， 陈魁俊， 薛雅楠， 王宁宁， 赵腾… - 力学学报, 2018 - lxxb.cstam.org.cn
细胞培养液在微流控生物反应器中受到外界物理场(如压力梯度或者电场)
作用流动而产生流体剪应力, 并进一步刺激种子细胞调控其内部基因的表达 …
作用流动而产生流体剪应力, 并进一步刺激种子细胞调控其内部基因的表达 …