Hepatorenal syndrome (HRS) remains one of the major therapeutic challenges in
hepatology today. The pathogenesis is complex, but the final common pathway seems to be …

Nitric oxide (NO) has diverse physiological and pathophysiological effects. The roles of NO
in the renal and cardiac dysfunction found in cirrhosis are reviewed. In the kidneys of …

Background & Aims Cholestatic liver disease is associated with dysregulated expression of
microRNAs (miRNAs). However, it remains unknown whether miRNAs are involved in the …

Study rationale Hepatorenal syndrome (HRS) is a life-threatening complication of end-stage
liver disease characterized by the rapid decline of kidney function. Herein, we explored the …

Microcomputed tomography of kidneys following chronic bile duct ligation. Background In
hepatic cirrhosis, renal sodium and water retention can occur prior to decreases in renal …

AIM: To evaluate the effects of dexamethasone on liver damage in rats with bile duct ligation.
METHODS: A total of 40 male Sprague-Dawley rats, weighing 165-205 g, were used in this …

Chronic bile duct ligation is associated with the development of oxidant injury, biliary
cirrhosis, portal hypertension, and a hyperdynamic circulation. We have previously …

Background The aim of our study was to investigate the antifibrotic and antioxidant effects of
Myrtus communis subsp. communis (MC) extract against liver injury and fibrosis occurring in …

We evaluated the involvement of nitric oxide (NO) in the early hemodynamic response to
uninephrectomy (UNX) in rats. Animals were uninephrectomized, and 48 h after removal of …

Hepatic fibrosis or increased liver collagen contents drive functional abnormalities that,
when extensive, may be life threatening. The purpose of this study was to assess the effects …