Natural products containing eight-membered carbocycles constitute a class of structurally
intriguing and biologically important molecules such as the famous diterpenes taxol and …

Cascade reactions (also known as domino reactions) are arguably the most powerful means
to achieve the construction of multiple ring systems in a single step. In this Tutorial Review …

Small molecules that modulate the 14-3-3 protein–protein interaction (PPI) network
represent valuable therapeutics and tool compounds. However, access has been lost to 14 …

There is a strong parallel between simple alcohol oxidation and carbonyl desaturation from
both strategic and tactical vantage points. As they both seek to extract hydrogen from an …

We have achieved the first total synthesis of bipolarolides A and B, which possess an
intriguing and complex 5/6/6/6/5 caged pentacyclic skeleton with seven contiguous …

The first asymmetric total synthesis of bioactive diterpenoid hypoestin A with an
unprecedented [5-8-5-3] tetracyclic skeleton is accomplished in 15 steps from commercially …

Comprehensive Summary Chemical investigation of Hedyosmum orientale led to the
identification of two terpenoid derivatives, dyosmunoids A and B (1 and 2) featuring two …

Covering: 2000 to 2023 This review presents the exceptional story of ophiobolin A (OphA)
and sphaeropsidin A (SphA), a sesterterpene and a diterpene, respectively, which were …

Sesterterpenoids are a very rare class of important natural products. Three new skeletal
spiro sesterterpenoids, named orientanoids A–C (1–3), were isolated from Hedyosmum …

Abstract Alterbrassicicene D (1) and 3 (11)‐epoxyhypoestenone (2) were synthesised via a
two‐phase approach featuring concise construction of the 5‐8‐5 tricyclic intermediate and a …