Epidermal growth factor receptor cell proliferation signaling pathways
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
Distinct functions of AKT isoforms in breast cancer: a comprehensive review
N Hinz, M Jücker - Cell Communication and Signaling, 2019 - Springer
Background AKT, also known as protein kinase B, is a key element of the PI3K/AKT
signaling pathway. Moreover, AKT regulates the hallmarks of cancer, eg tumor growth …
signaling pathway. Moreover, AKT regulates the hallmarks of cancer, eg tumor growth …
Akt signalling in health and disease
I Hers, EE Vincent, JM Tavaré - Cellular signalling, 2011 - Elsevier
Akt (also known as protein kinase B or PKB) comprises three closely related isoforms Akt1,
Akt2 and Akt3 (or PKBα/β/γ respectively). We have a very good understanding of the …
Akt2 and Akt3 (or PKBα/β/γ respectively). We have a very good understanding of the …
A positive feedback loop between Akt and mTORC2 via SIN1 phosphorylation
The mechanistic target of rapamycin complex 2 (mTORC2) regulates cell survival and
cytoskeletal organization by phosphorylating its AGC kinase substrates; however, little is …
cytoskeletal organization by phosphorylating its AGC kinase substrates; however, little is …
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
Deregulation of Akt/protein kinase B (PKB) is implicated in the pathogenesis of cancer and
diabetes. Akt/PKB activation requires the phosphorylation of Thr308 in the activation loop by …
diabetes. Akt/PKB activation requires the phosphorylation of Thr308 in the activation loop by …
The phosphatidylinositol 3-kinase–AKT pathway in human cancer
I Vivanco, CL Sawyers - Nature Reviews Cancer, 2002 - nature.com
One signal that is overactivated in a wide range of tumour types is the production of a
phospholipid, phosphatidylinositol (3, 4, 5) trisphosphate, by phosphatidylinositol 3-kinase …
phospholipid, phosphatidylinositol (3, 4, 5) trisphosphate, by phosphatidylinositol 3-kinase …
Cell signaling by receptor tyrosine kinases
J Schlessinger - Cell, 2000 - cell.com
(Hunter, 1998). RTKs play an important role in the control 1998; Jiang and Hunter, 1999).
Receptor dimerization is of most fundamental cellular processes including the further …
Receptor dimerization is of most fundamental cellular processes including the further …
ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions
Conserved signaling pathways that activate the mitogen-activated protein kinases (MAPKs)
are involved in relaying extracellular stimulations to intracellular responses. The MAPKs …
are involved in relaying extracellular stimulations to intracellular responses. The MAPKs …
The activation of Akt/PKB signaling pathway and cell survival
G Song, G Ouyang, S Bao - Journal of cellular and molecular …, 2005 - Wiley Online Library
Akt/PKB is a serine/threonine protein kinase that functions as a critical regulator of cell
survival and proliferation. Akt/PKB family comprises three highly homologous members …
survival and proliferation. Akt/PKB family comprises three highly homologous members …
The protein kinase B/Akt signalling pathway in human malignancy
KM Nicholson, NG Anderson - Cellular signalling, 2002 - Elsevier
Protein kinase B or Akt (PKB/Akt) is a serine/threonine kinase, which in mammals comprises
three highly homologous members known as PKBα (Akt1), PKBβ (Akt2), and PKBγ (Akt3) …
three highly homologous members known as PKBα (Akt1), PKBβ (Akt2), and PKBγ (Akt3) …