Glioblastoma (GBM) is one of the most aggressive cancers of the brain. Despite extensive
research over the last several decades, the survival rates for GBM have not improved and …

Coumarins are a class of compound with benzopyrone as their basic structure. Due to
abundant sources, easy synthesis, and various pharmacological activities, coumarins have …

This work describes about the synthesis and evaluation of substituted benzofuran
piperazines as potential anticancer agents. The synthesized candidates have been …

In recent years, the abnormal glucose metabolism of tumor cells has attracted increasing
attention. Abnormal glucose metabolism is closely related to the occurrence and …

Poor selectivity, potential systemic toxicity and drug resistance are the main challenges
associated with chemotherapeutic drugs. MCT1 and MCT4 and LAT1 play vital roles in …

The structural motif of coumarins is related with various biological activities and
pharmacological properties. Both natural coumarin extracted from various plants or a new …

Reprogramming of energy metabolism is a key hallmark of cancer. Most cancer cells display
a glycolytic phenotype, with increased glucose consumption and glycolysis rates, and …

As an oncometabolite, lactate plays a very important role in tumor proliferation, metastasis,
angiogenesis, immune escape and other tumor biological functions. Pharmacological …

The human monocarboxylate transporters (hMCTs/SLC16As) mediate the uptake of various
monocarboxylates. Several isoforms of hMCTs are expressed in cancerous tissue as well as …

Potent and dual monocarboxylate transporter (MCT) 1 and 4 inhibitors have been
developed for the first time as potential anticancer agents based on α-cyanocinnamic acid …