[HTML][HTML] Mechanisms and disease consequences of nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …
Role of the inflammasome in liver disease
M de Carvalho Ribeiro, G Szabo - Annual Review of Pathology …, 2022 - annualreviews.org
The involvement of inflammasomes in the proinflammatory response observed in chronic
liver diseases, such as alcohol-associated liver disease (ALD) and nonalcoholic fatty liver …
liver diseases, such as alcohol-associated liver disease (ALD) and nonalcoholic fatty liver …
NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice
AR Mridha, A Wree, AAB Robertson, MM Yeh… - Journal of …, 2017 - Elsevier
Background & Aims NOD-like receptor protein 3 (NLRP3) inflammasome activation occurs in
Non-alcoholic fatty liver disease (NAFLD). We used the first small molecule NLRP3 inhibitor …
Non-alcoholic fatty liver disease (NAFLD). We used the first small molecule NLRP3 inhibitor …
Immunology in the liver—from homeostasis to disease
The liver is a central immunological organ with a high exposure to circulating antigens and
endotoxins from the gut microbiota, particularly enriched for innate immune cells …
endotoxins from the gut microbiota, particularly enriched for innate immune cells …
Inflammasome activation and function in liver disease
G Szabo, J Petrasek - Nature reviews Gastroenterology & hepatology, 2015 - nature.com
Inflammation contributes to the pathogenesis of most acute and chronic liver diseases.
Inflammasomes are multiprotein complexes that can sense danger signals from damaged …
Inflammasomes are multiprotein complexes that can sense danger signals from damaged …
Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies
G Musso, M Cassader, R Gambino - Nature reviews Drug discovery, 2016 - nature.com
Non-alcoholic fatty liver disease—the most common chronic liver disease—encompasses a
histological spectrum ranging from simple steatosis to non-alcoholic steatohepatitis (NASH) …
histological spectrum ranging from simple steatosis to non-alcoholic steatohepatitis (NASH) …
[HTML][HTML] Alcohol's effect on host defense
G Szabo, B Saha - Alcohol research: current reviews, 2015 - ncbi.nlm.nih.gov
Alcohol affects many organs, including the immune system, with even moderate amounts of
alcohol influencing immune responses. Although alcohol can alter the actions of all cell …
alcohol influencing immune responses. Although alcohol can alter the actions of all cell …
[HTML][HTML] The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors
X Zhan, Q Li, G Xu, X Xiao, Z Bai - Frontiers in Immunology, 2023 - frontiersin.org
NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is a cytosolic pattern
recognition receptor (PRR) that recognizes multiple pathogen-associated molecular patterns …
recognition receptor (PRR) that recognizes multiple pathogen-associated molecular patterns …
Therapeutic potential of MCC950, a specific inhibitor of NLRP3 inflammasome
H Li, Y Guan, B Liang, P Ding, X Hou, W Wei… - European journal of …, 2022 - Elsevier
NOD-like receptor protein 3 (NLRP3), an important intracellular pattern recognition receptor,
is a component of the NLRP3 inflammasome along with apoptosis-associated speck-like …
is a component of the NLRP3 inflammasome along with apoptosis-associated speck-like …
AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity
Recognition of DNA by the cell is an important immunological signature that marks the
initiation of an innate immune response. AIM2 is a cytoplasmic sensor that recognizes …
initiation of an innate immune response. AIM2 is a cytoplasmic sensor that recognizes …