Epithelia are protected from adverse conditions by a mucous barrier. The secreted and
transmembrane mucins that constitute the mucous barrier are largely unrecognized as …

Abstract Mucin 1 (MUC1) is a heterodimeric protein formed by two subunits that is aberrantly
overexpressed in human breast cancer and other cancers. Historically, much of the early …

Pancreatic cancer remains a lethal malignancy with poor prognosis owing to therapeutic
resistance, frequent recurrence and the absence of treatment strategies that specifically …

MicroRNAs are important gene regulators that could play a profound role in tumorigenesis.
Our previous studies indicate that miR-145 is a tumor suppressor capable of inhibiting tumor …

MUC1 is a transmembrane mucin that is often overexpressed in metastatic cancers and
often used as a diagnostic marker for metastatic progression. The extracellular domain of …

Non–small cell lung cancer (NSCLC) cells are often associated with constitutive activation of
the phosphoinositide 3-kinase (PI3K)→ Akt→ mTOR pathway. The mucin 1 (MUC1) …

Mucins are high molecular weight glycoproteins that are involved in regulating diverse
cellular activities both in normal and pathological conditions. Mucin activity and localization …

Alteration of protein trafficking and localization is associated with several diseases, including
cystic fibrosis, breast cancer, colorectal cancer, leukemia and diabetes. Specifically …

Aberrant expression and signaling of epidermal growth factor receptor (ErbB) family receptor
tyrosine kinases, most notably that of ErbB2 and ErbB1, have been implicated in the …

The most common ovarian cancer is epithelial ovarian cancer (EOC) characterised by few
early symptoms, widespread peritoneal dissemination and ascites at advanced stages that …