Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. AML is
a heterogeneous malignancy characterized by distinct genetic abnormalities. Recent …

Hematological malignancies comprise a diverse set of lymphoid and myeloid neoplasms in
which normal hematopoiesis has gone awry and together account for∼ 10% of all new …

The Bmi-1 oncoprotein regulates proliferation and oncogenesis in human cells. Its
overexpression leads to senescence bypass in human fibroblasts and immortalization of …

Background B-lymphoma Moloney murine leukemia virus insertion region-1 (Bmi-1) acts as
an oncogene in various tumors, and its overexpression correlates with a poor outcome in …

In recent decades, cancer stem cells (CSCs) have been increasingly identified in many
malignancies. CSC-related signaling pathways and their functions provide new strategies …

Individual members of the retinoblastoma (Rb) tumor suppressor gene family serve critical
roles in the control of cellular proliferation and differentiation, but the extent of their …

High expression of BMI1 in acute myeloid leukemia (AML) cells is associated with an
unfavorable prognosis. Therefore, the effects of down-modulation of BMI1 in normal and …

BMI-1 oncogene is a member of the polycomb-group gene family and a transcriptional
repressor. Overexpression of BMI-1 has been identified in various human cancer tissues …

Abstract Polycomb Group (PcG) proteins form Polycomb Repressive Complexes (PRCs) that
function as epigenetic repressors of gene expression. The large variety of PcG proteins, in …

Bmi-1 and SALL4 are putative oncogenes that modulate stem cell pluripotency and play a
role in leukemogenesis. Murine Sall4 also has been shown to play an essential role in …