This narrative review highlights current evidence linking greater body fatness to risk of
various cancers, with focus on evidence from recent large cohort studies and pooled …

This year marks the 20th anniversary of the discovery of leptin, which has tremendously
stimulated translational obesity research. The discovery of leptin has led to realizations that …

Improving physical function and mobility in a continuously expanding elderly population
emerges as a high priority of medicine today. Muscle mass, strength/power, and maximal …

Overweight and obesity are health problems of epidemic proportions, increasing the risk not
only of cardiovascular disease and type 2 diabetes mellitus but also of various types of …

Lipid droplet formation is a defining histological feature in clear-cell renal cell carcinoma
(ccRCC) but the underlying mechanisms and importance of this biological behaviour have …

The past few years have provided substantial evidence for the vital role of the local tumor
microenvironment for various aspects of tumor progression. With obesity and its …

Almost 20 years have passed since the first laboratory evidence emerged that an abundant
message encoding a protein with homology to the C1q superfamily is highly specifically …

The prevalence of obesity, defined as a BMI of≥ 30· 0 kg/m2, has increased substantially
over previous decades to about 20% in industrialized countries, and a further increase is …

Metabolic syndrome (MS) is characterized by a group of metabolic disturbances which lead
to an enhanced risk of cardiovascular diseases and type 2 diabetes mellitus. MS constitutes …

Adiponectin, an adipocyte-secreted hormone that plays an important role in diabetes and
cardiovascular disease, may also be of importance in the development and progression of …