Despite efficient combination of the antiretroviral therapy (cART), which significantly
decreased mortality and morbidity of HIV-1 infection, a definitive HIV cure has not been …

Neurological involvement in HIV is often associated with cognitive impairment. Although
severe and progressive neurocognitive impairment has become rare in HIV clinics in the era …

Objective To test the hypothesis that coronavirus disease 2019 (COVID-19) has an impact
on the CNS by measuring plasma biomarkers of CNS injury. Methods We recruited 47 …

Background Metagenomic next-generation sequencing (NGS) of cerebrospinal fluid (CSF)
has the potential to identify a broad range of pathogens in a single test. Methods In a 1-year …

Cross-sectional studies show that around half of individuals infected with HIV-1 have some
degree of cognitive impairment despite the use of antiretroviral drugs. However, prevalence …

Objective: To characterize HIV-infected patients with neurosymptomatic cerebrospinal fluid
(CSF)'escape', defined as detectable CSF HIV RNA in the setting of treatment-suppressed …

Background Cognitive disorders are a common issue impacting those living with human
immunodeficiency virus (HIV). Effective antiretroviral treatment has lessened the severity but …

Early in the HIV epidemic, the central nervous system (CNS) was recognized as a target of
infection and injury in the advanced stages of disease. Though the most severe forms of HIV …

HIV-associated central nervous system (CNS) injury continues to be clinically significant in
the modern era of HIV infection and therapy. A substantial proportion of patients with …

BACKGROUND Persistence of HIV in sanctuary sites despite antiretroviral therapy (ART)
presents a barrier to HIV remission and may affect neurocognitive function. We assessed …