The dengue virus NS5 protein as a target for drug discovery
The non-structural protein 5 (NS5) of flaviviruses is the most conserved amongst the viral
proteins. It is about 900 kDa and bears enzymatic activities that play vital roles in virus …
proteins. It is about 900 kDa and bears enzymatic activities that play vital roles in virus …
Flavivirus: from structure to therapeutics development
R Zhao, M Wang, J Cao, J Shen, X Zhou, D Wang… - Life, 2021 - mdpi.com
Flaviviruses are still a hidden threat to global human safety, as we are reminded by recent
reports of dengue virus infections in Singapore and African-lineage-like Zika virus infections …
reports of dengue virus infections in Singapore and African-lineage-like Zika virus infections …
[HTML][HTML] Oxidative stress influences positive strand RNA virus genome synthesis and capping
Flaviviruses are 5′ capped positive-stranded RNA viruses that replicate their genomes
within endoplasmic reticulum-derived vesicles. Flaviviruses are well known to induce …
within endoplasmic reticulum-derived vesicles. Flaviviruses are well known to induce …
Structural biology of dengue virus enzymes: towards rational design of therapeutics
CG Noble, PY Shi - Antiviral research, 2012 - Elsevier
Abstract Development of anti-dengue therapy represents an urgent un-met medical need.
Towards antiviral therapy, recent advances in crystal structures of DENV enzymes have led …
Towards antiviral therapy, recent advances in crystal structures of DENV enzymes have led …
The viral RNA capping machinery as a target for antiviral drugs
Most viruses modify their genomic and mRNA 5′-ends with the addition of an RNA cap,
allowing efficient mRNA translation, limiting degradation by cellular 5′–3′ exonucleases …
allowing efficient mRNA translation, limiting degradation by cellular 5′–3′ exonucleases …
Identification of small molecule inhibitors of the Chikungunya virus nsP1 RNA capping enzyme
Chikungunya virus (CHIKV) is an arthropod-borne alphavirus. Alphaviruses are positive
strand RNA viruses that require a 5′ cap structure to direct translation of the viral …
strand RNA viruses that require a 5′ cap structure to direct translation of the viral …
Fused Tetrahydroquinolines Are Interfering with Your Assay
FM Bashore, J Annor-Gyamfi, Y Du… - Journal of Medicinal …, 2023 - ACS Publications
Tricyclic tetrahydroquinolines (THQs) have been repeatedly reported as hits across a
diverse range of high-throughput screening (HTS) campaigns. The activities of these …
diverse range of high-throughput screening (HTS) campaigns. The activities of these …
Discovery of an effective small-molecule allosteric inhibitor of New Delhi metallo-β-lactamase (NDM)
PW Thomas, EJ Cho, CR Bethel, T Smisek… - ACS Infectious …, 2022 - ACS Publications
To identify novel inhibitors of the carbapenemase New Delhi metallo-β-lactamase (NDM) as
possible therapeutic compounds, we conducted a high-throughput screen of a 43,358 …
possible therapeutic compounds, we conducted a high-throughput screen of a 43,358 …
New developments in flavivirus drug discovery
WM Kok - Expert opinion on drug discovery, 2016 - Taylor & Francis
Introduction: Flaviviruses are major causes of infectious disease. The vast global, social and
economic impact due to morbidity and mortality associated with diseases caused by these …
economic impact due to morbidity and mortality associated with diseases caused by these …