[HTML][HTML] Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators

A Nain-Perez, O Nilsson, A Lulla, L Håversen… - European Journal of …, 2023 - Elsevier
The liver isoform of pyruvate kinase (PKL) has gained interest due to its potential capacity to
regulate fatty acid synthesis involved in the progression of non-alcoholic fatty liver disease …

Unmasking the Warburg Effect: Unleashing the Power of Enzyme Inhibitors for Cancer Therapy

E Angulo-Elizari, L Gaviria-Soteras, I Zubiri… - Drugs and Drug …, 2023 - mdpi.com
The Warburg effect (or aerobic glycolysis), which was first described in 1926 by Otto
Heinrich Warburg, consists of the change in glucose metabolism in cancer cells. In normal …

Exploration of novel urolithin C derivatives as non-competitive inhibitors of liver pyruvate kinase

UM Battisti, L Monjas, F Akladios, J Matic, E Andresen… - Pharmaceuticals, 2023 - mdpi.com
The inhibition of liver pyruvate kinase could be beneficial to halt or reverse non-alcoholic
fatty liver disease (NAFLD), a progressive accumulation of fat in the liver that can lead …

[HTML][HTML] Sulfone-based human liver pyruvate kinase inhibitors–Design, synthesis and in vitro bioactivity

J Matić, F Akladios, UM Battisti, L Håversen… - European Journal of …, 2024 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a prevalent pathological condition characterised
by the accumulation of fat in the liver. Almost one-third of the global population is affected by …

[HTML][HTML] Discovery of Cell-Permeable Allosteric Inhibitors of Liver Pyruvate Kinase: Design and Synthesis of Sulfone-Based Urolithins

S Iqbal, MZ Islam, S Ashraf, W Kim… - International Journal of …, 2024 - mdpi.com
Metabolic dysfunction-associated fatty liver disease (MAFLD) presents a significant global
health challenge, characterized by the accumulation of liver fat and impacting a …

An experimental and theoretical study on mechanistic insights into urolithin-based ratiometric fluorescent probe for instant quantitative detection of fluoride ions

Y Wang, CC Yang, X Feng, Y Zhao - Talanta, 2024 - Elsevier
Fluoride detection has been playing an important role in chemical, biological, and medicinal
field, especially for keeping physical health and resisting environmental pollution. Herein, a …

ELLAGIC ACID: A REVIEW ON NATURAL SOURCES AND MEDICINAL IMPORTANCE

AM Stoenescu, I Trandafir - ANNALS OF THE …, 2023 - anale-horticultura.reviste.ucv.ro
Ellagic acid is a phenolic compound present in different plant species mainly in fruits and
vegetables (and other plant parts such as leaves, root, bark, kernel) but also in processed …

[PDF][PDF] PRECLINICAL AND CLINICAL USE OF ELLAGIC ACID: POTENTIAL EFFECTS AND APPROACHES

APDE BEYAZÇİÇEK - MULTIDISCIPLINARY APPROACH IN …, 2023 - iksadyayinevi.com
Tannins found in different plant species are polyphenolic compounds. These tannins, with
molecular weights ranging from 0.5 to 20 kDa, are soluble in water (Khanbabaee & van Ree …

ELLAGIC ACID: A REVIEW ON NATURAL SOURCES AND MEDICINAL IMPORTANCE.

S Ana-Maria, T Ion - Analele Universitatii din Craiova. Seria …, 2023 - search.ebscohost.com
Ellagic acid is a phenolic compound present in different plant species mainly in fruits and
vegetables (and other plant parts such as leaves, root, bark, kernel) but also in processed …

Urolithin-Based Ratiometric Fluorescent Probe: Instant Quantitative Monitoring for F

Y Wang, X Feng, Y Zhao - Available at SSRN 4533482 - papers.ssrn.com
Fluoride, as one of the biologically significant anions, is crucial to many chemical, biological,
and medicinal processes. Herein, a monitoring F-based on urolithin B fluorescent probe has …