Messenger RNA (mRNA)-based therapeutics hold the potential to cause a major revolution
in the pharmaceutical industry because they can be used for precise and individualized …

Adoptive transfer of chimeric antigen receptor (CAR) T lymphocytes is a powerful technology
that has revolutionized the way we conceive immunotherapy. The impressive clinical results …

Circular RNAs (circRNAs) are stable and prevalent RNAs in eukaryotic cells that arise from
back-splicing. Synthetic circRNAs and some endogenous circRNAs can encode proteins …

The design of Pfizer/BioNTech and Moderna mRNA vaccines involves many different types
of optimizations. Proper optimization of vaccine mRNA can reduce dosage required for each …

Summary 3′ untranslated region (3′ UTR) variants are strongly associated with human
traits and diseases, yet few have been causally identified. We developed the massively …

The hnRNPs (heterogeneous nuclear ribonucleoproteins) are RNA-binding proteins with
important roles in multiple aspects of nucleic acid metabolism, including the packaging of …

Ethylene signaling plays important roles in multiple aspects of plant growth and
development. Its functions in abiotic stress responses remain largely unknown. Here, we …

The present invention relates to a pharmaceutical composi tion comprising a modified
mRNA that is stabilized by sequence modifications and optimized for translation. The …

Heterogeneous nuclear ribonucleoproteins (hnRNPs) comprise a family of RNA-binding
proteins. The complexity and diversity associated with the hnRNPs render them …

In positive-stranded viruses, the genomic RNA serves as a template for both translation and
RNA replication. Using poliovirus as a model, we examined the interaction between these …