A structural view of SARS-CoV-2 RNA replication machinery: RNA synthesis, proofreading and final capping
The current coronavirus disease-2019 (COVID-19) pandemic is due to the novel coronavirus
SARS-CoV-2. The scientific community has mounted a strong response by accelerating …
SARS-CoV-2. The scientific community has mounted a strong response by accelerating …
The molecular virology of coronaviruses
E Hartenian, D Nandakumar, A Lari, M Ly… - Journal of Biological …, 2020 - ASBMB
Few human pathogens have been the focus of as much concentrated worldwide attention as
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19. Its …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19. Its …
The short-and long-range RNA-RNA interactome of SARS-CoV-2
The Coronaviridae is a family of positive-strand RNA viruses that includes SARS-CoV-2, the
etiologic agent of the COVID-19 pandemic. Bearing the largest single-stranded RNA …
etiologic agent of the COVID-19 pandemic. Bearing the largest single-stranded RNA …
Continuous and discontinuous RNA synthesis in coronaviruses
I Sola, F Almazán, S Zúñiga… - Annual review of …, 2015 - annualreviews.org
Replication of the coronavirus genome requires continuous RNA synthesis, whereas
transcription is a discontinuous process unique among RNA viruses. Transcription includes …
transcription is a discontinuous process unique among RNA viruses. Transcription includes …
The structure and functions of coronavirus genomic 3′ and 5′ ends
D Yang, JL Leibowitz - Virus research, 2015 - Elsevier
Coronaviruses (CoVs) are an important cause of illness in humans and animals. Most
human coronaviruses commonly cause relatively mild respiratory illnesses; however two …
human coronaviruses commonly cause relatively mild respiratory illnesses; however two …
[HTML][HTML] The SARS-CoV-2 subgenome landscape and its novel regulatory features
Summary Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is currently a global pandemic. CoVs are known to …
syndrome coronavirus 2 (SARS-CoV-2), is currently a global pandemic. CoVs are known to …
Nucleocapsid phosphorylation and RNA helicase DDX1 recruitment enables coronavirus transition from discontinuous to continuous transcription
CH Wu, PJ Chen, SH Yeh - Cell host & microbe, 2014 - cell.com
Coronaviruses contain a positive-sense single-stranded genomic (g) RNA, which encodes
nonstructural proteins. Several subgenomic mRNAs (sgmRNAs) encoding structural …
nonstructural proteins. Several subgenomic mRNAs (sgmRNAs) encoding structural …
Functional long-range RNA–RNA interactions in positive-strand RNA viruses
BL Nicholson, KA White - Nature Reviews Microbiology, 2014 - nature.com
Positive-strand RNA viruses are important human, animal and plant pathogens that are
defined by their single-stranded positive-sense RNA genomes. In recent years, it has …
defined by their single-stranded positive-sense RNA genomes. In recent years, it has …
Evaluation of a recombination-resistant coronavirus as a broadly applicable, rapidly implementable vaccine platform
Emerging and re-emerging zoonotic viral diseases are major threats to global health,
economic stability, and national security. Vaccines are key for reducing coronaviral disease …
economic stability, and national security. Vaccines are key for reducing coronaviral disease …
Transcriptional and epi-transcriptional dynamics of SARS-CoV-2 during cellular infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses subgenomic RNA
(sgRNA) to produce viral proteins for replication and immune evasion. We apply long-read …
(sgRNA) to produce viral proteins for replication and immune evasion. We apply long-read …