Treatments that block tumour necrosis factor (TNF) have major beneficial effects in several
autoimmune and rheumatic diseases, including rheumatoid arthritis. However, some …

The cytokine TNF signals via two distinct receptors, TNF receptor 1 (TNFR1) and TNFR2,
and is a central mediator of various immune-mediated diseases. Indeed, TNF-neutralizing …

Treg therapies are being tested in clinical trials in transplantation and autoimmune diseases,
however, the impact of inflammation on Tregs remains controversial. We challenged human …

The concept that a subset of T cells exists that specifically suppresses immune responses
was originally proposed over 50 years ago. It then took the next 30 years to solidify the …

Multiple sclerosis (MS) is an autoimmune disorder causing demyelination and
neurodegeneration in the central nervous system. MS is characterized by disturbed motor …

Extensive infiltration of tumor-associated macrophages was correlated poor prognosis in
anaplastic thyroid cancer (ATC). However, the heterogeneity and characteristics of the ATC …

Tumor necrosis factor (TNF) receptor-2 (TNFR2) has attracted considerable interest as a
target for immunotherapy. Indeed, using oligomeric fusion proteins of single chain-encoded …

Treg cells have been initially described as gatekeepers for the control of autoimmunity, as
they can actively suppress the activity of other immune cells. However, their role goes …

An imbalance of TNF signalling in the inflammatory milieu generated by meningeal immune
cell infiltrates in the subarachnoid space in multiple sclerosis (MS), and its animal model …

TNF signaling is an essential regulator of cellular homeostasis. Through its two receptors
TNFR1 and TNFR2, soluble versus membrane-bound TNF enable cell death or survival in a …