Rapidly evolving genes in pathogens: methods for detecting positive selection and examples among fungi, bacteria, viruses and protists
The ongoing coevolutionary struggle between hosts and pathogens, with hosts evolving to
escape pathogen infection and pathogens evolving to escape host defences, can generate …
escape pathogen infection and pathogens evolving to escape host defences, can generate …
Detecting signatures of balancing selection to identify targets of anti-parasite immunity
GD Weedall, DJ Conway - Trends in parasitology, 2010 - cell.com
Parasite antigen genes might evolve under frequency-dependent immune selection. The
distinctive patterns of polymorphism that result can be detected using population genetic …
distinctive patterns of polymorphism that result can be detected using population genetic …
[HTML][HTML] Malaria parasite clag3 genes determine channel-mediated nutrient uptake by infected red blood cells
W Nguitragool, AAB Bokhari, AD Pillai, K Rayavara… - Cell, 2011 - cell.com
Development of malaria parasites within vertebrate erythrocytes requires nutrient uptake at
the host cell membrane. The plasmodial surface anion channel (PSAC) mediates this …
the host cell membrane. The plasmodial surface anion channel (PSAC) mediates this …
[HTML][HTML] Population genomic scan for candidate signatures of balancing selection to guide antigen characterization in malaria parasites
Acquired immunity in vertebrates maintains polymorphisms in endemic pathogens, leading
to identifiable signatures of balancing selection. To comprehensively survey for genes under …
to identifiable signatures of balancing selection. To comprehensively survey for genes under …
[HTML][HTML] An essential dual-function complex mediates erythrocyte invasion and channel-mediated nutrient uptake in malaria parasites
D Ito, MA Schureck, SA Desai - Elife, 2017 - elifesciences.org
Malaria parasites evade immune detection by growth and replication within erythrocytes.
After erythrocyte invasion, the intracellular pathogen must increase host cell uptake of …
After erythrocyte invasion, the intracellular pathogen must increase host cell uptake of …
Molecular approaches to diversity of populations of apicomplexan parasites
HP Beck, D Blake, ML Dardé, I Felger… - International journal for …, 2009 - Elsevier
Apicomplexan parasites include many parasites of importance either for livestock or as
causative agents of human diseases. The importance of these parasites has been …
causative agents of human diseases. The importance of these parasites has been …
[HTML][HTML] A Genetically Hard-Wired Metabolic Transcriptome in Plasmodium falciparum Fails to Mount Protective Responses to Lethal Antifolates
K Ganesan, N Ponmee, L Jiang, JW Fowble… - PLoS …, 2008 - journals.plos.org
Genome sequences of Plasmodium falciparum allow for global analysis of drug responses
to antimalarial agents. It was of interest to learn how DNA microarrays may be used to study …
to antimalarial agents. It was of interest to learn how DNA microarrays may be used to study …
[HTML][HTML] An epigenetic antimalarial resistance mechanism involving parasite genes linked to nutrient uptake
P Sharma, K Wollenberg, M Sellers, K Zainabadi… - Journal of Biological …, 2013 - ASBMB
Acquired antimalarial drug resistance produces treatment failures and has led to periods of
global disease resurgence. In Plasmodium falciparum, resistance is known to arise through …
global disease resurgence. In Plasmodium falciparum, resistance is known to arise through …
[HTML][HTML] Complex nutrient channel phenotypes despite Mendelian inheritance in a Plasmodium falciparum genetic cross
A Gupta, AAB Bokhari, AD Pillai, AK Crater… - PLoS …, 2020 - journals.plos.org
Malaria parasites activate a broad-selectivity ion channel on their host erythrocyte
membrane to obtain essential nutrients from the bloodstream. This conserved channel …
membrane to obtain essential nutrients from the bloodstream. This conserved channel …
[HTML][HTML] Malaria parasites use a soluble RhopH complex for erythrocyte invasion and an integral form for nutrient uptake
MA Schureck, JE Darling, A Merk, J Shao, G Daggupati… - Elife, 2021 - elifesciences.org
Malaria parasites use the RhopH complex for erythrocyte invasion and channel-mediated
nutrient uptake. As the member proteins are unique to Plasmodium spp., how they interact …
nutrient uptake. As the member proteins are unique to Plasmodium spp., how they interact …