The ongoing coevolutionary struggle between hosts and pathogens, with hosts evolving to
escape pathogen infection and pathogens evolving to escape host defences, can generate …

Parasite antigen genes might evolve under frequency-dependent immune selection. The
distinctive patterns of polymorphism that result can be detected using population genetic …

Development of malaria parasites within vertebrate erythrocytes requires nutrient uptake at
the host cell membrane. The plasmodial surface anion channel (PSAC) mediates this …

Acquired immunity in vertebrates maintains polymorphisms in endemic pathogens, leading
to identifiable signatures of balancing selection. To comprehensively survey for genes under …

Malaria parasites evade immune detection by growth and replication within erythrocytes.
After erythrocyte invasion, the intracellular pathogen must increase host cell uptake of …

Apicomplexan parasites include many parasites of importance either for livestock or as
causative agents of human diseases. The importance of these parasites has been …

Genome sequences of Plasmodium falciparum allow for global analysis of drug responses
to antimalarial agents. It was of interest to learn how DNA microarrays may be used to study …

Acquired antimalarial drug resistance produces treatment failures and has led to periods of
global disease resurgence. In Plasmodium falciparum, resistance is known to arise through …

Malaria parasites activate a broad-selectivity ion channel on their host erythrocyte
membrane to obtain essential nutrients from the bloodstream. This conserved channel …

Malaria parasites use the RhopH complex for erythrocyte invasion and channel-mediated
nutrient uptake. As the member proteins are unique to Plasmodium spp., how they interact …