Discovered more than 30 years ago, the angiotensin AT2 receptor (AT2R) has evolved from
a binding site with unknown function to a firmly established major effector within the …

The classic renin-angiotensin system (RAS) is described as a circulating hormone system
focused on cardiovascular and body water regulation, with angiotensin II as its major …

Angiotensin II (ANG II), generated by activation of local renin-angiotensin systems, is
believed to play an important role in tissue repair and remodeling, in part via transforming …

The classic renin–angiotensin system (RAS) was initially described as a hormone system
designed to mediate cardiovascular and body water regulation, with angiotensin II as its …

Considerable evidence now suggests that the precursors and enzymes necessary for the
formation and degradation of biologically active forms of angiotensins are present in brain …

The renin-angiotensin systems (RASs) regulate blood pressure, kidney function, and salt
and water homeostasis. Modulation of RAS is central in the intensive care unit spectrum of …

Dipeptidyl peptidase III (DPP III), the sole member and representative of the M49 family of
metallopeptidases, is a zinc‐dependent aminopeptidase. It sequentially hydrolyses …

The brain renin-angiotensin system (RAS) has available the necessary functional
components to produce the active ligands angiotensins II (AngII), angiotensin III …

Hyperactivity of the renin–angiotensin–aldosterone system through the angiotensin II (Ang
II)/Ang II type 1 receptor (AT1-R) axis constitutes a hallmark of hypertension. Recent findings …

Background The renin–angiotensin system (RAS) functions as both a circulating endocrine
system and a tissue paracrine/autocrine system. As a circulating peptide, angiotensin II (Ang …