Immune responses regulated by cannabidiol
JM Nichols, BLF Kaplan - Cannabis and cannabinoid research, 2020 - liebertpub.com
Introduction: Cannabidiol (CBD) as Epidiolex®(GW Pharmaceuticals) was recently
approved by the US Food and Drug Administration (FDA) to treat rare forms of epilepsy in …
approved by the US Food and Drug Administration (FDA) to treat rare forms of epilepsy in …
Cannabidiol as a therapeutic target: evidence of its neuroprotective and neuromodulatory function in Parkinson's disease
F Patricio, AA Morales-Andrade… - Frontiers in …, 2020 - frontiersin.org
The phytocannabinoids of Cannabis sativa L. have, since ancient times, been proposed as a
pharmacological alternative for treating various central nervous system (CNS) disorders …
pharmacological alternative for treating various central nervous system (CNS) disorders …
[HTML][HTML] Cannabinoids and epilepsy
Cannabis has been used for centuries to treat seizures. Recent anecdotal reports,
accumulating animal model data, and mechanistic insights have raised interest in cannabis …
accumulating animal model data, and mechanistic insights have raised interest in cannabis …
Cannabinoids as key regulators of inflammasome signaling: a current perspective
Inflammasomes are cytoplasmic inflammatory signaling protein complexes that detect
microbial materials, sterile inflammatory insults, and certain host-derived elements …
microbial materials, sterile inflammatory insults, and certain host-derived elements …
Direct modulation of the outer mitochondrial membrane channel, voltage-dependent anion channel 1 (VDAC1) by cannabidiol: a novel mechanism for cannabinoid …
Cannabidiol (CBD) is a non-psychoactive plant cannabinoid that inhibits cell proliferation
and induces cell death of cancer cells and activated immune cells. It is not an agonist of the …
and induces cell death of cancer cells and activated immune cells. It is not an agonist of the …
Microglia and their LAG3 checkpoint underlie the antidepressant and neurogenesis-enhancing effects of electroconvulsive stimulation
N Rimmerman, H Verdiger, H Goldenberg… - Molecular …, 2022 - nature.com
Despite evidence implicating microglia in the etiology and pathophysiology of major
depression, there is paucity of information regarding the contribution of microglia-dependent …
depression, there is paucity of information regarding the contribution of microglia-dependent …
Cannabinoids decrease the th17 inflammatory autoimmune phenotype
Cannabinoids, the Cannabis constituents, are known to possess anti-inflammatory
properties but the mechanisms involved are not understood. Here we show that the main …
properties but the mechanisms involved are not understood. Here we show that the main …
Microarray and pathway analysis reveal distinct mechanisms underlying cannabinoid-mediated modulation of LPS-induced activation of BV-2 microglial cells
Cannabinoids are known to exert immunosuppressive activities. However, the mechanisms
which contribute to these effects are unknown. Using lipopolysaccharide (LPS) to activate …
which contribute to these effects are unknown. Using lipopolysaccharide (LPS) to activate …
Modulation of astrocyte activity by cannabidiol, a nonpsychoactive cannabinoid
The astrocytes have gained in recent decades an enormous interest as a potential target for
neurotherapies, due to their essential and pleiotropic roles in brain physiology and …
neurotherapies, due to their essential and pleiotropic roles in brain physiology and …
Microglia NLRP3 inflammasome and neuroimmune signaling in substance use disorders
During the last decade, substance use disorders (SUDs) have been increasingly recognized
as neuroinflammation-related brain diseases. Various types of abused drugs (cocaine …
as neuroinflammation-related brain diseases. Various types of abused drugs (cocaine …