Mycobacterium tuberculosis uses sophisticated secretion systems, named 6 kDa early
secretory antigenic target (ESAT6) protein family secretion (ESX) systems (also known as …

Mycobacterium marinum is an opportunistic pathogen inducing infection in fresh and marine
water fish. This pathogen causes necrotizing granuloma like tuberculosis, morbidity and …

The type VII protein secretion system (T7SS) plays a critical role in the virulence of human
pathogens including Mycobacterium tuberculosis and Staphylococcus aureus. Here, we …

Streptomycetes, soil-dwelling mycelial bacteria that form sporulating aerial branches, have
an exceptionally large number of predicted secreted proteins, including many exported via …

Recent evidence shows that mycobacteria have developed novel and specialized secretion
systems for the transport of extracellular proteins across their hydrophobic, and highly …

Mycobacterium marinum, a ubiquitous pathogen of fish and amphibia, is a near relative of
Mycobacterium tuberculosis, the etiologic agent of tuberculosis in humans. The genome of …

Type VII secretion systems (T7SSs) have a key role in the secretion of effector proteins in
non-pathogenic mycobacteria and pathogenic mycobacteria such as Mycobacterium …

The phylum Actinobacteria harbors many important human pathogens and also provides
one of the richest sources of natural products, including numerous antibiotics and other …

The pe/ppe genes represent one of the most intriguing aspects of the M ycobacterium
tuberculosis genome. These genes are especially abundant in pathogenic mycobacteria …

The Esx secretion pathway is conserved across Gram-positive bacteria. Esx-1, the best-
characterized system, is required for virulence of Mycobacterium tuberculosis, although its …