Introduction The overall goal of the Alzheimer's Disease Neuroimaging Initiative (ADNI) is to
validate biomarkers for Alzheimer's disease (AD) clinical trials. ADNI is a multisite …

Cognitive training in MCI may stimulate pre-existing neural reserves or recruit neural
circuitry as “compensatory scaffolding” prompting neuroplastic reorganization to meet task …

Recent reports suggest declines in the age-specific risk of Alzheimer's dementia in higher
income Western countries. At the same time, investigators believe that worldwide trends of …

Background: Hippocampal atrophy is a characteristic of Alzheimer's disease (AD). However,
alterations in structural connectivity (number of connecting fibers) between the hippocampus …

Introduction: The diagnosis of Alzheimer's disease (AD) requires the presence of amyloid
and tau pathology, but it remains unclear how they affect the structural network in the pre …

Background: Early prediction of disease progression in patients with amnestic mild cognitive
impairment (aMCI) is important for early diagnosis and intervention of Alzheimer's disease …

Key points The parasympathetic nervous system (PNS) is critical for adaptation to
environment demands. Alzheimer's disease (AD), via frontal compensatory processes, may …

Mild traumatic brain injury (mTBI) initiating long-term effects on white matter integrity
resembles brain-aging changes, implying an aging process accelerated by mTBI. This …

It is proven that oxidative stress has a pivotal role in the process of neurodegeneration. The
use of antioxidants is an attractive method to prevent the incidence of neurodegenerative …

This study introduces a novel brain connectome matrix, track‐weighted PET connectivity
(twPC) matrix, which combines positron emission tomography (PET) and diffusion magnetic …