Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …

A major feature of Alzheimer's disease (AD) pathology is the plaque composed of
aggregated amyloid-β (Aβ) peptide. Although these plaques may have harmful properties …

Alzheimer disease (AD) is a progressive and deleterious neurodegenerative disorder that
affects mostly the elderly population. At the moment, no effective treatments are available in …

N-acetyl cysteine (NAC), as a nutritional supplement, is a greatly applied antioxidant in vivo
and in vitro. NAC is a precursor of L-cysteine that results in glutathione elevation …

The contribution of the Ubiquitin-Proteasome System (UPS) to mitophagy has been largely
attributed to the E3 ubiquitin ligase Parkin. Here we show that in response to the oxidative …

Alzheimer's disease (AD) is the most common neurodegenerative disease and is
characterized by neurofibrillary tangles (NFTs) composed of Tau protein. α-Lipoic acid (LA) …

Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …

Proteinopathy and excessive production of reactive oxygen species (ROS), which are the
principal features observed in the Alzheimer's disease (AD) brain, contribute to neuronal …

The blood‐brain barrier (BBB), as a crucial gate of brain‐blood molecular exchange, is
involved in the pathogenesis of multiple neurological diseases. Oxidative stress is caused …

Mitochondria are uniquely poised to play a pivotal role in neuronal cell survival or death
because they are regulators of both energy metabolism and cell death pathways. Extensive …