Age, apolipoprotein E ε4 (APOE) and chromosomal sex are well-established risk factors for
late-onset Alzheimer's disease (LOAD; AD). Over 60% of persons with AD harbor at least …

▪ Abstract Statins are potent inhibitors of cholesterol biosynthesis. In clinical trials, statins are
beneficial in the primary and secondary prevention of coronary heart disease. However, the …

Objective.—To examine more closely the association between apolipoprotein E (APOE)
genotype and Alzheimer disease (AD) by age and sex in populations of various ethnic and …

Objective: To determine the influence of type 2 diabetes mellitus on the risk of dementia and
AD. Background: Both dementia and diabetes are frequent disorders in elderly people …

One of the primary genetic risk factors for Alzheimer's disease (AD) is the presence of the Ɛ4
allele of apolipoprotein E (APOE). APOE is a polymorphic lipoprotein that is a major …

Background Dementia affects an estimated 10% of the population older than 65 years.
Because vascular and lipid-related mechanisms are thought to have a role in the …

Background This is an update of a Cochrane review first published in 2001. At that stage
there was insufficient evidence to recommend statins for the prevention of Alzheimer's …

A hallmark of all forms of Alzheimer's disease (AD) is an abnormal accumulation of the β-
amyloid protein (Aβ) in specific brain regions. Both the generation and clearance of Aβ are …

Alzheimer's disease (AD) is the most common neurodegenerative disorder and the most
prevalent cause of dementia with ageing. Pharmacological treatment of AD is based on the …

Objective: To study the difference in risk for dementing diseases between men and women.
Background: Previous studies suggest women have a higher risk for dementia than men …