Breast cancer is a heterogeneous disease that affects one anatomic site, yet is
phenotypically variable. 1, 2 The identification of different biological subtypes occurs …

Simple Summary Triple-negative breast cancer (TNBC) is a highly aggressive subtype of
breast cancer that cannot be treated with endocrine therapy and Her2-targeted therapy …

Abstract The 13th St Gallen International Breast Cancer Conference (2013) Expert Panel
reviewed and endorsed substantial new evidence on aspects of the local and regional …

Purpose There is no consensus on what constitutes adequate negative margins in breast-
conserving therapy (BCT). We systematically review the evidence on surgical margins in …

The appropriate negative margin width for women undergoing breast‐conserving surgery for
both ductal carcinoma in situ (DCIS) and invasive carcinoma is controversial. This review …

Background Metastatic breast cancer is not a curable disease, but women with metastatic
disease are living longer. Surgery to remove the primary tumour is associated with an …

Background Our group previously published data showing that patients could be stratified by
constructed molecular subtype with respect to locoregional recurrence (LRR)-free survival …

Objective: To examine whether contralateral prophylactic mastectomy (CPM) is associated
with improved survival, incidence of contralateral breast cancer (CBC), and recurrence in …

Aim To evaluate trends in the risk of local recurrences after breast-conserving treatment
(BCT) and to examine the impact of local recurrence (LR) on distant relapse-free survival in …

Importance Trastuzumab is a life-saving therapy but is associated with symptomatic and
asymptomatic left ventricular ejection fraction (LVEF) decline. We report the cardiac toxic …