The quest for new approaches in myocarditis and inflammatory cardiomyopathy
S Heymans, U Eriksson, J Lehtonen… - Journal of the American …, 2016 - jacc.org
Myocarditis is a diverse group of heart-specific immune processes classified by clinical and
histopathological manifestations. Up to 40% of dilated cardiomyopathy is associated with …
histopathological manifestations. Up to 40% of dilated cardiomyopathy is associated with …
The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of …
Activation of the immune system in heart failure (HF) has been recognized for over 20 years.
Initially, experimental studies demonstrated a maladaptive role of the immune system …
Initially, experimental studies demonstrated a maladaptive role of the immune system …
STNM01, the RNA oligonucleotide targeting carbohydrate sulfotransferase 15, as second-line therapy for chemotherapy-refractory patients with unresectable …
T Fujisawa, T Tsuchiya, M Kato, M Mizuide… - …, 2023 - thelancet.com
Background The impact of stroma-targeting therapy on tumor immune suppression is largely
unexplored. An RNA oligonucleotide, STNM01, has been shown to repress carbohydrate …
unexplored. An RNA oligonucleotide, STNM01, has been shown to repress carbohydrate …
Profound impact of decline in N-acetylgalactosamine-4-sulfatase (Arylsulfatase B) on molecular pathophysiology and human diseases
JK Tobacman, S Bhattacharyya - International Journal of Molecular …, 2022 - mdpi.com
The enzyme N-acetylgalactosamine-4-sulfatase (Arylsulfatase B; ARSB) was originally
identified as a lysosomal enzyme which was deficient in Mucopolysaccharidosis VI (MPS VI; …
identified as a lysosomal enzyme which was deficient in Mucopolysaccharidosis VI (MPS VI; …
Pivotal role of carbohydrate sulfotransferase 15 in fibrosis and mucosal healing in mouse colitis
K Suzuki, S Arumugam, J Yokoyama, Y Kawauchi… - PLoS …, 2016 - journals.plos.org
Induction of mucosal healing (MH) is an important treatment goal in inflammatory bowel
disease (IBD). Although the molecular mechanisms underlying MH in IBD is not fully …
disease (IBD). Although the molecular mechanisms underlying MH in IBD is not fully …
Phase 1 clinical study of siRNA targeting carbohydrate sulphotransferase 15 in Crohn's disease patients with active mucosal lesions
K Suzuki, J Yokoyama, Y Kawauchi… - Journal of Crohn's …, 2017 - academic.oup.com
Abstract Background and Aims: Carbohydrate sulphotransferase 15 [CHST15] is a specific
enzyme biosynthesizing chondroitin sulphate E that binds various pathogenic mediators and …
enzyme biosynthesizing chondroitin sulphate E that binds various pathogenic mediators and …
Nanocarriers assisted siRNA gene therapy for the management of cardiovascular disorders
Cardiovascular diseases (CVDs), primarily myocardial infarction (MI), atherosclerosis,
hypertension and congestive heart failure symbolize the foremost cause of death in almost …
hypertension and congestive heart failure symbolize the foremost cause of death in almost …
Add-on multiple submucosal injections of the RNA oligonucleotide GUT-1 to anti-TNF antibody treatment in patients with moderate-to-severe ulcerative colitis: an open …
K Suzuki, Y Sameshima, J Yokoyama, S Terai… - Inflammation and …, 2024 - Springer
Abstract Background Carbohydrate sulfotransferase 15 (CHST15) is an enzyme
biosynthesizing matrix glycosaminoglycan that modulates tissue remodeling. We evaluated …
biosynthesizing matrix glycosaminoglycan that modulates tissue remodeling. We evaluated …
A proteomic analysis of atrial fibrillation in a prospective longitudinal cohort (AGES-Reykjavik study)
T Jonmundsson, AE Steindorsdottir, TR Austin… - Europace, 2023 - academic.oup.com
Aims Atrial fibrillation (AF) is associated with high risk of comorbidities and mortality. Our aim
was to examine causal and predictive relationships between 4137 serum proteins and …
was to examine causal and predictive relationships between 4137 serum proteins and …
MicroRNA-29a suppresses cardiac fibroblasts proliferation via targeting VEGF-A/MAPK signal pathway
H Tao, ZW Chen, JJ Yang, KH Shi - International journal of biological …, 2016 - Elsevier
Cardiac fibroblasts proliferation is the most important pathophysiological character of
cardiac fibrosis while the underlying mechanisms are still incompletely known. MicroRNAs …
cardiac fibrosis while the underlying mechanisms are still incompletely known. MicroRNAs …