Executive summary “Depression is a disorder of mood, so mysteriously painful and elusive
in the way it becomes known to the self—to the mediating intellect—as to verge close to …

Depression represents a global mental health concern, and disproportionally affects women
as they are twice more likely to be diagnosed than men. In this review, we provide a …

Using behavioral, pharmacological, and molecular methods, lots of studies reveal that
depression is closely related to the abnormal neural plasticity processes occurring in the …

Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …

Chronic stress constitutes a major risk factor for depression that can disrupt various aspects
of homeostasis, including the gut microbiome (GM). We have recently shown that GM …

Volumetric reductions in the hippocampus and medial prefrontal cortex (mPFC) are among
the most well-documented neural abnormalities in major depressive disorder (MDD) …

Brain‐derived neurotrophic factor (BDNF) is a neurotrophin that is vital to the survival,
growth, and maintenance of neurons in key brain circuits involved in emotional and …

Many patients with major depressive disorder (MDD) are reported to have higher levels of
multiple inflammatory cytokines including interleukin 6 (IL-6). Recent studies both pre …

Depression is a major health problem with a high prevalence and a heavy socioeconomic
burden in western societies. It is associated with atrophy and impaired functioning of cortico …

Major depression is a prevalent illness that increases the risk of several neurological
conditions. These include stroke, cardiovascular disease, and dementia including …