Origins, structures, and functions of circulating DNA in oncology

AR Thierry, S El Messaoudi, PB Gahan, P Anker… - Cancer and metastasis …, 2016 - Springer
While various clinical applications especially in oncology are now in progress such as
diagnosis, prognosis, therapy monitoring, or patient follow-up, the determination of structural …

Circulating microRNAs in breast cancer: novel diagnostic and prognostic biomarkers

R Hamam, D Hamam, KA Alsaleh, M Kassem… - Cell death & …, 2017 - nature.com
Effective management of breast cancer depends on early diagnosis and proper monitoring
of patients' response to therapy. However, these goals are difficult to achieve because of the …

MicroRNA: function, detection, and bioanalysis

H Dong, J Lei, L Ding, Y Wen, H Ju, X Zhang - Chemical reviews, 2013 - ACS Publications
Mature microRNAs (miRNAs) are a class of evolutionally conserved, single-stranded, small
(approximately 19− 23 nucleotides), endogenously expressed, and non-protein-coding …

Hypoxic enhancement of exosome release by breast cancer cells

HW King, MZ Michael, JM Gleadle - BMC cancer, 2012 - Springer
Background Exosomes are nanovesicles secreted by tumour cells which have roles in
paracrine signalling during tumour progression, including tumour-stromal interactions …

MicroRNAs in body fluids—the mix of hormones and biomarkers

MA Cortez, C Bueso-Ramos, J Ferdin… - Nature reviews Clinical …, 2011 - nature.com
Since the discovery of microRNAs (miRNAs), the study of these small noncoding RNAs has
steadily increased and more than 10,000 papers have already been published. The great …

Cancer stem cell secretome in the tumor microenvironment: a key point for an effective personalized cancer treatment

J López de Andrés, C Griñán-Lisón, G Jiménez… - Journal of hematology & …, 2020 - Springer
Cancer stem cells (CSCs) represent a tumor subpopulation responsible for tumor metastasis
and resistance to chemo-and radiotherapy, ultimately leading to tumor relapse. As a …

Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis

N Kosaka, H Iguchi, T Ochiya - Cancer science, 2010 - Wiley Online Library
In the past several years, the importance of microRNA (miRNA) in cancer cells has been
recognized. Proper control of miRNA expression is essential for maintaining a steady state …

New concepts in cancer biomarkers: circulating miRNAs in liquid biopsies

E Larrea, C Sole, L Manterola, I Goicoechea… - International journal of …, 2016 - mdpi.com
The effective and efficient management of cancer patients relies upon early diagnosis and/or
the monitoring of treatment, something that is often difficult to achieve using standard tissue …

HIF induces human embryonic stem cell markers in cancer cells

J Mathieu, Z Zhang, W Zhou, AJ Wang, JM Heddleston… - Cancer research, 2011 - AACR
Low oxygen levels have been shown to promote self-renewal in many stem cells. In tumors,
hypoxia is associated with aggressive disease course and poor clinical outcomes …

Circulating microRNAs: new biomarkers in diagnosis, prognosis and treatment of cancer

A Allegra, A Alonci, S Campo… - International …, 2012 - spandidos-publications.com
MicroRNAs (miRNAs) are small non-coding, endogenous, single-stranded RNAs. MiRNAs
have been implicated in different areas such as the immune response, neural development …