Covering: 2008 to 2018 Over the last decade more than two hundred single natural products
were confirmed as natural allosteric modulators (alloNPs) of proteins. The compounds are …

Acute heart attack is the primary cause of cardiovascular-related death worldwide. A
common treatment is reperfusion of ischemic tissue, which can cause irreversible damage to …

The utilization of opioids in clinical pharmacology started after the extraction of morphine
from the opium poppy Papaver somniferum in 1806 with its use further intensified after the …

Mitochondrial dynamics, determining mitochondrial morphology, quality and abundance,
have recently been implicated in myocardial ischemia and reperfusion (MI/R) injury. The …

Opioids regulate various physiological and pathophysiological functions, including cell
proliferation, immune function, obesity, and neurodegenerative disorders. They have been …

The apelin receptor (APJ) and the opioid-related nociceptin receptor 1 (ORL1) are family AG
protein-coupled receptors that participate in a variety of physiological processes. The …

Objective: Naringenin, a flavonoid found in citrus fruits, has notably diverse pharmacological
properties. In the present study, we investigated the antinociceptive and anti-inflammatory …

Opioid drugs are the first line of defense in severe pain but the adverse effects associated
with opioids are considered as a serious issue worldwide. Acupuncture/electroacupuncture …

Opioids are complex drugs that produce profit (most importantly analgesia) as well as a
myriad of adverse effects including gastrointestinal motility disturbances, abuse and …

Osteoarthritis (OA) represents the highest degenerative disorder. Because cartilage erosion
is a common pathological alteration in OA, targeting some key metalloproteinases such as …