Phase transitions of associative biomacromolecules

RV Pappu, SR Cohen, F Dar, M Farag, M Kar - Chemical Reviews, 2023 - ACS Publications
Multivalent proteins and nucleic acids, collectively referred to as multivalent associative
biomacromolecules, provide the driving forces for the formation and compositional …

A conceptual framework for understanding phase separation and addressing open questions and challenges

T Mittag, RV Pappu - Molecular cell, 2022 - cell.com
Macromolecular phase separation is being recognized for its potential importance and
relevance as a driver of spatial organization within cells. Here, we describe a framework …

Phase separation of protein mixtures is driven by the interplay of homotypic and heterotypic interactions

M Farag, WM Borcherds, A Bremer, T Mittag… - Nature …, 2023 - nature.com
Prion-like low-complexity domains (PLCDs) are involved in the formation and regulation of
distinct biomolecular condensates that form via phase separation coupled to percolation …

Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expanded conformations

M Farag, SR Cohen, WM Borcherds, A Bremer… - Nature …, 2022 - nature.com
Biomolecular condensates form via coupled associative and segregative phase transitions
of multivalent associative macromolecules. Phase separation coupled to percolation is one …

Peptide design and self-assembly into targeted nanostructure and functional materials

NJ Sinha, MG Langenstein, DJ Pochan… - Chemical …, 2021 - ACS Publications
Peptides have been extensively utilized to construct nanomaterials that display targeted
structure through hierarchical assembly. The self-assembly of both rationally designed …

Polysaccharide nanoparticles: From fabrication to applications

A Plucinski, Z Lyu, BVKJ Schmidt - Journal of Materials Chemistry B, 2021 - pubs.rsc.org
Polysaccharides have attracted considerable attention in a broad range of applications in
recent years, which is due to their remarkable features such as biocompatibility …

[HTML][HTML] Coacervates as models of membraneless organelles

NA Yewdall, AAM André, T Lu, E Spruijt - Current Opinion in Colloid & …, 2021 - Elsevier
Coacervates are condensed liquid-like droplets, usually formed with oppositely charged
polymeric molecules. They have been studied extensively in colloid and interface science …

[HTML][HTML] Recent advances in polysaccharides based biomaterials for drug delivery and tissue engineering applications

A Sood, A Gupta, G Agrawal - Carbohydrate Polymer Technologies and …, 2021 - Elsevier
In this paper, a spotlight is shown on polysaccharides based biomaterials which have
surfaced as a versatile platform for different biomedical applications including drug delivery …

Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy

P Zhao, X Xia, X Xu, KKC Leung, A Rai, Y Deng… - Nature …, 2021 - nature.com
A key challenge for the effective treatment of gastrointestinal diseases including
inflammatory bowel disease is to develop an orally administered drug delivery system …

Encapsulation and delivery systems of cinnamon essential oil for food preservation applications

W Zhang, P Ezati, A Khan, E Assadpour… - Advances in Colloid and …, 2023 - Elsevier
Food safety threats and deterioration due to the invasion of microorganisms has led to
economic losses and food-borne diseases in the food industry; so, development of natural …